Hematological parameters in high altitude residents:Tibetan natives versus Han migrants  

作　　者：Tian-yi WU Feng-yun LIU Ling HU Chun-yin WEI Zhi-gang WANG Ouzhou-LOUBU Chao-ying CU Bianba Xue-bin QI Bing SU 

机构地区：[1]Department of Hypoxic Physiology and Mountain Sickness,High Altitude Medical Research Institute [2]High Altitude Medical Research Centre,University of Tibet [3]Department of Hematological Laboratory,Qinghai Cardiovascular Disease Hospital [4]State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Academy of Science

出　　处：《中国应用生理学杂志》2014年第6期516-525,共10页Chinese Journal of Applied Physiology

基　　金：supported by the "973" National Basic Research Program(2012 CB 518202,and "Pre-973" National Basic Research Program(2012 CB 722506)

摘　　要：Objective Aim of our study was to compare hematological parameters in Tibetan natives with those in Han migrants living on the Tibet plateau in order to determine the potential effects of age,gender,and ethnicity on hematological response to hypoxia.Methods Blood hemoglobin(Hb,g/dl),hematocrit(Hct,%),red blood cells(RBC,10~6/mm^3) were measured in 3 588 healthy Tibetan natives and 3 371 Han migrants ranging in age from 5 to 72 years,living at a mean altitudes of 2 664 m,3 813 m,4 525 m and 5 226 m.Results Hemoglobin(Hb) concentration analysis was made by multiple regression equations relating hemoglobin to altitude and age.For 2 093 Han males,Hb =9.612+ 0.001440xaltitude+ 0.06148 xage.For1 948 Tibetan males,Hb =12.202+ 0.000462xaltitude+ 0.02893 xage.For 1 278 Han females,Hb = 10.858+0.000939xaltitude+ 0.02632 xage.For 1 640 Tibetan females,Hb =11.402+ 0.000626xaltitude+ 0.00412 xage.Each of the four equations was statistically significant(P<0.001),and had variance(r2) of 0.86 or more,indicating that altitude and age accounted for at least 85%of the variation in hemoglobin levels.The coefficients for altitude and for age were higher(P<0.05) in Han males than in Tibetan males and higher(P<0.05)in Han females than in Tibetan females.The Tibetan postmenopausal females had higher Hb values than premenopausal females only presented at altitude above 4 000 m while this phenomenon was beginning at altitude of 2 664 m among Han females.Conclusion We conclude that gender and increasing age in Tibetans are associated with lower hemoglobin values than those in Han at high altitude,and we speculate that genetic factors seems to be important.Objective Aim of our study was to compare hematological parameters in Tibetan natives with those in Han migrants living on the Tibet plateau in order to determine the potential effects of age,gender,and ethnicity on hematological response to hypoxia.Methods Blood hemoglobin（Hb,g/dl）,hematocrit（Hct,%）,red blood cells（RBC,10~6/mm^3） were measured in 3 588 healthy Tibetan natives and 3 371 Han migrants ranging in age from 5 to 72 years,living at a mean altitudes of 2 664 m,3 813 m,4 525 m and 5 226 m.Results Hemoglobin（Hb） concentration analysis was made by multiple regression equations relating hemoglobin to altitude and age.For 2 093 Han males,Hb =9.612＋ 0.001440xaltitude＋ 0.06148 xage.For1 948 Tibetan males,Hb =12.202＋ 0.000462xaltitude＋ 0.02893 xage.For 1 278 Han females,Hb = 10.858＋0.000939xaltitude＋ 0.02632 xage.For 1 640 Tibetan females,Hb =11.402＋ 0.000626xaltitude＋ 0.00412 xage.Each of the four equations was statistically significant（P〈0.001）,and had variance（r2） of 0.86 or more,indicating that altitude and age accounted for at least 85%of the variation in hemoglobin levels.The coefficients for altitude and for age were higher（P〈0.05） in Han males than in Tibetan males and higher（P〈0.05）in Han females than in Tibetan females.The Tibetan postmenopausal females had higher Hb values than premenopausal females only presented at altitude above 4 000 m while this phenomenon was beginning at altitude of 2 664 m among Han females.Conclusion We conclude that gender and increasing age in Tibetans are associated with lower hemoglobin values than those in Han at high altitude,and we speculate that genetic factors seems to be important.

关 键 词：高海拔地区 西藏高原 血液参数 移民生活 汉族 多元回归方程 血红蛋白 居民 

分 类 号：Q987[生物学—遗传学] X503.225[生物学—人类学]