Ghrelin与胃肠道疾病关系的研究进展  

Relationship between ghrelin and gastrointestinal diseases

作　　者：唐健[1] 林江[1] 

机构地区：[1]上海中医药大学附属曙光医院消化科,上海市200021

出　　处：《世界华人消化杂志》2014年第35期5447-5453,共7页World Chinese Journal of Digestology

基　　金：重点科技攻关基金资助项目;No.11DZ1972903~~

摘　　要：Ghrelin是一种新发现的28肽脑肠肽,主要由胃黏膜分泌,有酰基化和非酰基化两种形式,酰基化是其主要的活性形式.Ghrelin是生长激素释放激素受体的内源性配体,通过旁分泌、自分泌和内分泌多种途径,发挥着增进摄食、促进胃酸分泌、促进胃肠道运动、保护胃黏膜、抑制炎症反应等多种胃肠道生理调节作用.近来研究发现,多种胃肠道疾病,如幽门螺杆菌感染、消化性溃疡、功能性消化不良、炎症性肠病、胰腺炎、恶性肿瘤等都存在ghrelin水平的异常变化,提示ghrelin可能参与这些疾病的病理生理机制.Ghrelin有可能成为诊断胃肠道疾病和判断其预后的一个指标,同时也可能成为治疗胃肠疾病药物的一个新靶点.Ghrelin is a newly found 28-amino acid brain-gut peptide, which is mainly secreted by the gastric mucosa. It has two forms, acyl-ghrelin and des-acyl ghrelin, and the former is the major active form. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and plays an important role in regulating food intake, gastric acid secretion, gastrointestinal motility, gastric mucosa protection, and inhibition of inflammatory reaction in paracrine, autocrine and endocrine manners. Recent studies have found that ghrelin levels are abnormal in a variety of gastrointestinal diseases, such as Helicobacter pylori infection, peptic ulcer, functional dyspepsia, inflammatory bowel disease, pancreatitis, tumors and so on, suggesting that ghrelin may be involved in the pathogenesis of these diseases. Ghrelin may become an index for disease diagnosis and prognosis evaluation and a new target for treatment of gastrointestinal diseases.

关 键 词：GHRELIN 生理作用 胃肠道疾病 

分 类 号：R57[医药卫生—消化系统]