中医复方对肝硬化腹水患者腹水中LDH、GLU、SAAG的改变和临床疗效  

Traditional Chinese medicine compound for patients with liver cirrhosis and ascites: Efficacy and effect on serum lactate dehydrogenase, glucose, and serum ascites albumin gradient

作　　者：刘浩[1] 

机构地区：[1]川北医学院中西医临床医学系,四川省南充市637000

出　　处：《世界华人消化杂志》2014年第35期5521-5525,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨中医复方对肝硬化腹水患者中检测指标改变和临床疗效.方法:对四川省南充市顺庆区川北医学院2010-04/2014-04收治的肝硬化腹水患者进行中药复方的前瞻性研究.采用随机数字表分组方法将134例患者随机分为观察组(67例)和对照组(67例).其中,观察组采用中药复方(肝硬化腹水方)治疗,对照组采用临床常规治疗.比较两组患者治疗前后临床疗效和检验指标乳酸脱氢酶(lactate dehydrogenase,LDH)、空腹血糖(glucose,GLU)、血清腹水白蛋白梯度(serum ascites albumin gradient,SAAG)水平的改善程度.结果:观察组患者总有效率为91.04%,对照组患者总有效率为77.61%.两组患者有效率比较,差异有统计学意义(P<0.05);两组患者治疗前后检测指标LDH、GLU、SAAG水平均有不同程度改善,其组内治疗前后比较,差异有统计学意义(P值分别为0.239、0.001、0.913、0.166、0.649和<0.001);治疗后,观察组检测指标GLU和SAAG较对照组明显改善,组间比较差异有统计学意义(P<0.05).结论:中医方剂治疗肝硬化腹水患者能有效的改善患者临床疗效,改善检测指标LDH、GLU、SAAG水平,值得临床上广泛应用.AIM： To investigate clinical efficacy of traditional Chinese medicine compound in patients with liver cirrhosis and ascites. METHODS： A prospective study was performed from April 2010 to April 2014, and patients with liver cirrhosis and ascites admitted to our hospital were included. A total of 134 patients were randomly divided into either an observation group （n = 67） or a control group （n = 67）. The observation group were treated with traditional Chinese medicine compound （recipe for liver cirrhosis associated ascites）, and the control group received routine clinical treatment. Serum lactate dehydrogenase （LDH）, glucose （GLU）, serum ascites albumin gradient （SAAG） and clinical efficacy were compared between the two groups of patients before and after treatment. RESULTS： The total effective rate was significantly higher in the observation group than in the control group （91.04% vs 77.61%, P 〈 0.05）. LDH, GLU, SAAG levels were significantly improved after treatment in both groups （P 〈 0.05）, and the improvement of GLU and SAAG was more significant in the observation group than in the control group （P 〈 0.05）. CONCLUSION： Traditional Chinese medicine compound can effectively improve clinical efficacy and LDH, GLU, and SAAG levels in patients with cirrhosis and ascites.

关 键 词：肝硬化腹水 临床疗效 乳酸脱氢酶 空腹血糖 血清腹水白蛋白梯度 

分 类 号：R259[医药卫生—中西医结合]