(3-烯丙氧基苯基氨基羰基)-N-对硝基苄氧基羰基-反-4-羟基-L-吡咯烷的合成研究  

Synthesis of(3-Allyloxy-benziaminocarbonyl)-N-p-nitrobenzyloxycarbonyl-trans-4-hydroxy-L-pyrrolidine

作　　者：陈红[1] 杨艺虹[1] 张珩[1] 张国龙[1] 王贝[1] 

机构地区：[1]武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北武汉430073

出　　处：《精细化工中间体》2014年第6期42-45,共4页Fine Chemical Intermediates

摘　　要：以4R-羟基-L-脯氨酸为原料,与氯甲酸对硝基苄酯反应进行氨基保护、再与间氨基苯甲酸烯丙酯缩合得到目标化合物(3-烯丙氧基苯基氨基羰基)-N-对硝基苄氧基羰基-反-4-羟基-L-吡咯烷。对反应物配比、催化剂、反应时间和温度等因素进行了研究,确定了缩合优化条件为:二氯甲烷作溶剂,25℃下反应4 h。优化条件下,缩合收率达86.1%。目标产物结构经IR、1H NMR和MS确证。The titled compound was prepared from trans-4-L-hydroxy-proline by its reaction with 4-nitrobenzyl chloroformate, followed by condensation with 3-amino-allylbenzoate. The affecting factors including the ratio of the raw materials, the catalyst, the reaction time and temperature were investigated. The structure of the target compound was confirmed by IR, 1H NMR and MS spectra.

关 键 词：抗生素 碳青霉烯 厄他培南 

分 类 号：TQ463.5[化学工程—制药化工]