陈皮姜软胶囊质量标准研究  

Study on Quality Standard for Chenpijiang Soft Capsule

作　　者：韩亮[1] 刘昌辉[1] 宓穗卿[1] 王宁生[1] 

机构地区：[1]广州中医药大学临床药理研究所,广东广州510405

出　　处：《中药新药与临床药理》2015年第1期95-98,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(81403179);广东省教育厅育苗工程资助项目(2013LYM_0046)

摘　　要：目的建立中药复方制剂陈皮姜软胶囊的质量标准。方法采用TLC法鉴别陈皮姜软胶囊中干姜;用高效液相色谱法对制剂中6-姜酚进行定量分析。结果定性鉴别分离度好,专属性强;6-姜酚的含量测定线性范围为42.08~420.8μg·m L-1（r=0.9998,n=6）,平均回收率为100.80%（RSD=1.33,n=6）。结论所建立之方法准确可靠、灵敏度高、专属性强,可有效控制陈皮姜软胶囊的质量。Objective To establish the quality standard for Chenpijiang soft capsule. Methods Rhizoma Zingiberis of Chenpijiang soft capsule was identified by thin layer chromatography（TLC）, 6-gingerol in the soft capsule was determined by high performance liquid chromatography（HPLC）. Results The characteristic identification by TLC was distinct and highly specific. The quantitative evaluation of 6-gingerol had the linear range of 42.08~420.8 μg·mL-1（r=0.9998, n=6）, and the average recovery was 100.80 %（RSD=1.33, n=6）. Conclusion The established method is reliable,accurate and specific,and it can be used for quality control of Chenpijiang soft capsule.

关 键 词：陈皮姜软胶囊 质量标准 高效液相色谱 6-姜酚 

分 类 号：R284.1[医药卫生—中药学]