心力衰竭患者血清中可溶性ST2和脑钠肽相关性分析  

Correlation Analysis of Serum Soluble ST2 and Brain Natriuretic Peptidein Patients with Heart Failure Severity

作　　者：韩冰[1] 李妮[1] 聂荷香[1] 孙彬[1] 王迪[1] 朱蕾[1] 董梅[1] 

机构地区：[1]解放军第309医院检验科,北京100091

出　　处：《标记免疫分析与临床》2015年第1期4-6,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的通过测定心力衰竭患者血清中可溶性ST2(sST2)和脑钠肽(BNP)的水平,明确sST2和BNP的相关性,探讨其对心力衰竭的诊断价值。方法选取2013年5月至2014年6月来我院就诊的心力衰竭患者60例,按纽约心脏协会(NYHA)心功能标准进行分级。所有入组病例均详细询问病史,入院后在常规检查的基础上完善sST2和BNP的检查。结果观察组血清sST2、BNP水平明显高于健康对照组,差异有统计学意义(P<0.01);观察组血清sST2和BNP水平在不同分级组间差异有统计学意义(P<0.05),心功能级别越高,血清sST2和BNP水平也越高。Spearman相关性分析显示,sST2和BNP血浓度水平随着心力衰竭严重程度的加重而加重。ROC曲线显示,sST2和BNP曲线下面积分别为0.922和0.881。结论血清sST2、BNP与心力衰竭患者严重程度呈相关性,可用于心力衰竭的诊断。Objective To explore the correlation of Serum soluble ST2 （sST2） and brain natriuretic peptide （BNP） in patients with heart failure and its clinical diagnostic values. Methods 60 cases of heart failure were classified according to the New York Heart Association （NYHA） heart function standard. All patients were asked in detail about medical history and completed sST2 and BNP check on the basis of routine examination after admission. Results The serum levels of sST2 and BNP in the Observation group were higher than those in the control group （P 〈0.01 ）. There were significant differences in sST2 and BNP blood concentration levels between different classification groups （ P 〈 0.05 ）. The higher level of cardiac function was wit higher serum sST2 and .BNP. Spearman correlation analysis showed that the serum levels of ST2 and BNP increased with the severity of heart failure. ROC curve showed that the correlation coefficients for sST2 and BNP were 0.922 and 0. 881. Conclusion The serum levels of sST2 and BNP are positively related to the severity of heart failure, thus it can be used for the diagnosis of heart failure.

关 键 词：心力衰竭 可溶性ST2(sST2) 脑钠肽(BNP) 

分 类 号：R541.6[医药卫生—心血管疾病]