磷酸二酯酶5抑制剂改善阿尔茨海默病认知功能的研究进展  

Research progress of phosphodiesterase 5 inhibitors to improve cognitive function in Alzheimer's disease

作　　者：金凤[1,2] 龚其海[1] 马越鸣[2] 石京山[1,2] 

机构地区：[1]遵义医学院药理学教研室暨贵州省基础药理重点实验室,遵义563000 [2]上海中医药大学,上海201203

出　　处：《中国新药杂志》2015年第2期162-165,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81160400);贵州省科技厅(黔科合J字[2009]2147号);贵州省中医药管理局项目(QZYY2010;D-274);遵义医学院招标课题项目(2013F-686)

摘　　要：近年研究发现磷酸二酯酶5(Phosphodiesterase-5,PDE5)在阿尔茨海默病(Alzheimer's disease,AD)发生发展过程的作用倍受关注,其抑制剂可明显增强动物和人的认知功能,其机制与干预AD发病过程如改善血管功能紊乱、促进神经递质释放、促进神经再生及抗凋亡等作用有关。因此,PDE5抑制剂可能为AD的治疗提供新方向。本文中,笔者结合国内外相关研究进展,重点阐述PDE5抑制剂对AD的保护作用及其相关作用机制。In recent years the role of phosphodiesterase 5 in the development and progression of Alzheimer＇s disease（ AD） has been paid much attention. PDE5 inhibitors can significantly enhance cognitive function in animals and humans,which may be related with the intervention in the pathogenesis of AD such as improving vascular disorders,promoting neurotransmitters release,promoting neuroregeneration,anti-apoptotic,and anti-inflammatory effects. Therefore,PDE5 inhibitors may provide a new direction for the AD treatment. In this article,the protective effects of PDE5 inhibitors on AD and their related mechanisms were expounded based on the relevant research progress at home and abroad.

关 键 词：阿尔茨海默病 磷酸二酯酶5 学习记忆 信号通路 神经递质 神经再生 

分 类 号：R971[医药卫生—药品]