肺癌根治术中胸腔置留注射用甘露聚糖肽的观察  

Efficacy of mannatide for injection in thoracic cavity in radical surgery of lung cancer

作　　者：李龙[1] 彭勇[1] 冉鹏[1] 王元汉[1] 

机构地区：[1]贵州省肿瘤医院胸外科,贵阳550000

出　　处：《中国新药杂志》2015年第2期186-188,共3页Chinese Journal of New Drugs

摘　　要：目的:观察肺癌根治术中胸腔置留注射用甘露聚糖肽(力尔凡)对术后胸腔引流量及胸腔引流管拔出时间的影响。方法:回顾性分析我院胸外科2012年6月至2013年11月的118例肺癌根治术患者。其中,69例患者(19例胸腔镜手术,50例开胸手术)术中胸腔置留甘露聚糖肽,方法为手术结束前将甘露聚糖肽50 mg溶于250 m L生理盐水,注入胸膜腔内并使其充分接触胸腔内组织,观察10 min后常规关闭胸腔;49例(13例胸腔镜手术,36例开胸手术)术中胸腔未置留甘露聚糖肽。收集入组患者的术后引流总量并记录胸腔引流管拔出时间,并进行统计分析。结果:胸腔镜手术组中,甘露聚糖肽不能明显缩短胸腔引流管的拔出时间,但能够显著减少术后胸腔引流总量(P<0.05);常规开胸手术组中,甘露聚糖肽能明显缩短胸腔引流管拔出时间并减少术后胸腔引流总量(P<0.05)。结论:肺癌根治术中胸腔置留甘露聚糖肽可有效减少术后胸腔引流总量,能在一定程度上缩短胸腔引流管的拔出时间。Objective： To observe the efficacy of putting mannatide into the thorax during the operation on pleural effusions and the time of pulling out thoracic drainage tube after lung cancer radical surgery. Methods： Totally 118 patients with lung cancer undergoing radical surgery in our hospital from Jun 2012 to Nov 2013 were studied retrospectively. Mannatide was used in 69 patients（ 19 of VATS; 50 of thoracotomy） during the operation.Mannatide（ 50 mg） was dissolved in 250 m L saline,and then put into the thorax for 10 min before sternum closed.Forty-nine patients（ 13 of VATS; 36 of thoracotomy） did not receive mannatide during the operation. The pleural effusions and the time of pulling out chest tube in all the patients were recorded and analyzed. Results： In VATS group,the time of pulling out thoracic drainage tube did not change,but the pleural effusions were significantly reduced after putting mannatide into the thorax during the operation（ P〈0. 05）. In thoracotomy group,mannatide reduced both the pleural effusions and the time of pulling out thoracic drainage tube after operations（ P〈0. 05）.Conclusion： Putting mannatide into the thorax during the lung cancer radical surgery reduces the pleural effusions;it can reduce the time of pulling out thoracic drainage tube in part of the patients.

关 键 词：肺癌根治术 注射用甘露聚糖肽 引流量 胸腔 

分 类 号：R979.1[医药卫生—药品]