联合检测Hcy、Cysc及hs-CRP对妊娠期高血压疾病的意义  

The significance of joint detection of Hcy, CysC and hs-CRP for the diagnosis of HDP

作　　者：王挺[1] 连炬飞[1] 周永贤[1] 郭莉[1] 陈汉彪[1] 

机构地区：[1]广东省妇幼保健院,广东广州510010

出　　处：《热带医学杂志》2014年第12期1570-1572,共3页Journal of Tropical Medicine

摘　　要：目的探讨血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)及超敏-C反应蛋白(hs-CRP)联合检测对诊断妊娠期高血压疾病(HDP)的临床价值。方法选取86例妊娠期高血压疾病患者(HDP组)和96例正常妊娠孕妇(对照组),分别检测血清Hcy、Cys C和hs-CRP,并对结果进行分析比较。结果 HDP组与对照组比较,重度HDP组与轻度HDP组比较,Hcy、Cys C和hs-CRP差异均有统计学意义(P<0.05)。HDP组Hcy与Cys C、hs-CRP呈显著正相关(r=0.592、0.668),且Hcy、Cys C和hs-CRP浓度与HDP病情轻重呈正相关(r=0.759、0.266、0.365)。结论 HDP患者血清Hcy、Cysc和hs-CRP浓度与HDP病情轻重呈正相关,联合检测对诊断妊娠期高血压疾病及其病情进展、预后判断具有重要的指导意义。Objective To evaluate the clinical value of serum homocysteine（Hcy）, cystalin C（Cys C） and high-sensitivity C-reactive protein（hs-CRP） joint detect for the diagnosis of hypertensive disorders complicating pregnancy（HDP）.Method Serum levels of Hcy, Cys C and hs-CRP of 86 HDP patients（HDP group） and 96 normal pregnant women（control group） were measured, analyzed and compared. Results Comparing HDP group and control group, severe HDP group and mild HDP group, there were significances differences in serum levels of Hcy, Cys C and hs-CRP（P〈0.05）. Significant positive correlation exist between Hcy and Cysc, hs-CRP in HDP group（r =0.592,0.668）, and the serum levels of Hcy,Cys C and hs-CRP is positively correlated with the severity of HDP（r=0.759,0.266,0.365）. Conclusion The serum levels of Hcy, Cys C and hs-CRP in HDP patient is positively correlated with the severity of HDP. Joint detection of the serum levels of Hcy, Cys C and hs-CRP is important for the diagnosis of HDP and illness progression and prognosis.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 胱抑素C 超敏-C反应蛋白 

分 类 号：R714.246[医药卫生—妇产科学]