母婴血型不合新生儿溶血的相关检测结果分析  

The results of correlation detection in maternal fetal blood group incompatibility hemolytic disease of the newborn

作　　者：赵小燕[1] 粟兵[1] 双艳琦 肖潇[1] 陈龙[1] 邓文斌[1] 贺小艳[1] 陈雪梅[1] 

机构地区：[1]四川省绵阳市中心医院输血科,四川成都621000

出　　处：《热带医学杂志》2014年第12期1608-1609,1626,共3页Journal of Tropical Medicine

摘　　要：目的探讨母婴血型不合新生儿溶血病（HDN）相关检测结果的相关性。方法对绵阳市中心医院2008年1月至2013年12月期间新生儿科180例发生新生儿溶血的患儿进行血型及三项实验检测（直接抗人球实验、血清游离抗体测试ABO血型系统以外的抗体筛查）,并对产妇进行血型及Ig G抗体效价测定。结果三项实验可证实新生儿溶血病81例,可凝5例,不明确94例。产妇Ig G效价≥512时HDN发病率为91.66%,Ig G效价为256~时HDN发病率为72.92%,Ig G效价为128~时HDN发病率为57.69%,Ig G效价为64~时HDN发病率为28.57%,Ig G效价〈64时HDN发病率为1.64%,各组间新生儿溶血病发病率差异有统计学意义（P〈0.05）。结论产妇Ig G抗体效价与新生儿溶血病发病率呈正相关,因此在夫妇血型不合时孕妇应定期监测Ig G抗体效价,可降低HDN发病率。Objective To investigate the correlation between the incompatibility detection result and maternal fetal blood group incompatibility hemolytic disease of the newborn. Methods Neonatal blood type and three experiments, and the maternal blood group and lg G antibody titer were determined for 180 cases of neonatal hemolysis in our hospital from2008.1 to 2013.12. Results The three experiments confirmed 81 cases of hemolytic disease of the newborn, 5 suspected cases, and 94 unclear cases. Maternal titer of lg G ≥ 512 the incidence of HDN was 96.5%; lg G titer was 256, the incidence of HDN was 75.4%; lg G titer was 128, the incidence of HDN was 50.3%; Ig G titer was 64, the incidence of HDN was 32.1%; Ig G titer was 〈64, the incidence of HDN was 1.61%. The neonatal hemolytic disease incidence was significantly different among different groups（P〈0.05）. Conclusion Maternal lg G antibody titer and hemolytic disease of the newborn incidence was positively correlated, so incompatible lg G antibody titer of the pregnant women of the incompatible couples should be monitored to reduce the incidence rate of HDN.

关 键 词：母婴血型不合 新生儿溶血症 IgG效价 

分 类 号：R722.18[医药卫生—儿科]