普罗布考及其衍生物防治动脉粥样硬化和血管成形术后再狭窄的研究现状及进展  

Current Situation and Prospect in the Research of Probucol and its Derivatives in Treating Atherosclerosis and Restenosis

作　　者：朱洪(综述)[1] 孙爱军(审校)[1] 

机构地区：[1]复旦大学附属中山医院,上海市心血管病研究所,上海市200032

出　　处：《中国动脉硬化杂志》2014年第10期1062-1066,共5页Chinese Journal of Arteriosclerosis

基　　金：国家重点基础研究发展计划973项目(2011CB503905)

摘　　要：心脑血管疾病已成为中国居民首位死亡原因。作为冠心病和脑卒中的共同致病基础,动脉粥样硬化的发生是一个多因素引起的复杂病理过程。普罗布考以其独特的抗氧化、抗炎、降胆固醇及改善内皮功能等作用应用于临床治疗动脉粥样硬化和血管成形术后再狭窄已有多年。本文从普罗布考的作用机制、临床应用和其衍生物的开发利用等方面对普罗布考防治动脉粥样硬化和血管成形术后再狭窄的研究现状和进展做一综述。Nowadays,cardio-cerebrovascular disease is a major cause of death in China. As a common pathogenic basis of coronary heart disease and stroke,atherosclerosis is a complex pathological process which is controlled by multiple factors. With its unique effects on anti-oxidation,anti-inflammation,cholesterol-lowering and improving endothelial function,probucol has been clinically used in preventing and treating atherosclerosis and coronary artery restenosis after angioplasty for decades. This review describes the situation and prospect in the research of probucol and its derivatives in treating atherosclerosis and restenosis from several aspects such as its mechanism,clinical application and the exploitation of its derivatives.

关 键 词：普罗布考 动脉粥样硬化 胆固醇 炎症 氧化 

分 类 号：R5[医药卫生—内科学]