心脑血管病危险因素与颈动脉粥样硬化的相关性  

Correlation Between Risk Factors of Cardio-/ Cerebro-Vascular Disease and Carotid Atherosclerosis

作　　者：刘金玉[1,2] 赵颖馨[1] 刘振东[1] 宋洪斌[1,2] 叶琳[3] 

机构地区：[1]山东省医学科学院基础医学研究所心脑血管病防治研究中心,山东省济南市250062 [2]济南大学山东省医学科学院医学与生命科学院,山东省济南市250022 [3]山东省立医院,山东省济南市250021

出　　处：《中国动脉硬化杂志》2014年第11期1105-1108,共4页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金(ZR2011HQ053;ZR2011HL053);山东省科技发展计划项目(2012GGB14094)

摘　　要：目的探讨心脑血管病危险因素与颈动脉粥样硬化的相关性。方法选择2010年8月~2013年8月健康体检者916例,依据合并危险因素的数量将受试者分为4组,即0个危险因素组（对照组）226例,1个危险因素组239例,2个危险因素组234例,≥3个危险因素组217例。所有受试者均进行颈动脉超声检测及血生化检测。结果对照组患者斑块发生率为7.52%,1个危险因素组为15.06%,2个危险因素组为23.93%,≥3个危险因素组为45.16%,从对照组到合并≥3个危险因素组斑块发生率显著上升（P〈0.01）。4组受试者IMT分别为0.94±0.32 mm、1.12±0.34 mm、1.25±0.33 mm及1.37±0.39 mm,斑块Crouse积分分别为0.24±0.64、0.58±1.21、0.85±1.26及1.32±1.64。从对照组到合并≥3个危险因素组IMT及斑块Crouse积分逐渐增高（P〈0.01）。Logistic回归分析显示,1个危险因素组颈动脉粥样硬化斑块发生率为对照组的1.27倍,2个危险因素组为2.31倍,≥3个危险因素组为4.68倍（P〈0.01）。结论危险因素之间对缺血性脑血管病高危人群颈动脉粥样硬化及斑块的发生具有显著的联合协同作用。Aim To investigate the correlation between risk factors of cardiovascular and cerebro-vascular disease and carotid atherosclerosis. Methods From August 2010 to August 2013,916 subjects were eligibly enrolled from health care center. Participants were classified into four groups,namely,0 risk factor group（ control group,n =226）,1 risk factor group（ n = 239）,2 risk factors group（ n = 234）,and ≥3 risk factors group（ n = 217） according to the incorporated number of risk factors. Carotid artery ultrasound examination and blood biochemical tests were performed in all participants. Results The incidence of plaque was 7. 52% in control group,15. 06% in 1 risk factor group,23. 93% in 2 risk factors group,and 45. 16% in ≥3 risk factors group. From control group to ≥3 risk factors group,incidence of carotid artery plaque was significantly increased（ P 〈 0. 01）. Intima-media thickness was 0. 94 ± 0. 32 mm in control group,1. 12 ± 0. 34 mm in 1 risk factor group,1. 25 ± 0. 33 mm in 2 risk factors group,and 1. 37 ± 0. 39 mm in ≥3 risk factors group. Crouse scores was 0. 24 ± 0. 64 in control group,0. 58 ± 1. 21 in 1 risk factor group,0. 85 ± 1. 26 in2 risk factors group,and 1. 32 ± 1. 64 in ≥3 risk factors group. There were significant increments in carotid artery intima-media thickness and Crouse scores from control group to ≥3 risk factors group（ P 〈 0. 01）. Control group was as referee,the incidence of plaque was 1. 27 times in 1 risk factor group,2. 31 times in 2 risk factor group,and 4. 68 times in≥3 risk factors group（ all P 〈 0. 01）. Conclusion There was combined synergy effect between risk factors on carotid atherosclerosis and plaque.

关 键 词：危险因素 动脉粥样硬化 动脉硬化斑块 

分 类 号：R5[医药卫生—内科学]