慢性幽门螺杆菌感染对颈动脉粥样硬化患者血清氧化型低密度脂蛋白水平的影响  

Chronic Helicobacter Pylori Infection in Patients with Carotid Atherosclerosis and the Influence of Serum Oxidized Low Density Lipoprotein Level

作　　者：雷鸣[1] 周权[1] 张艳[1] 夏丹妮[1] 白驹 

机构地区：[1]常德市第一人民医院检验科,湖南省常德市415003

出　　处：《中国动脉硬化杂志》2014年第11期1114-1117,共4页Chinese Journal of Arteriosclerosis

基　　金：湖南省卫生厅医药卫生科技计划课题(B2013-146)

摘　　要：目的探讨幽门螺杆菌(Hp)感染与血清中氧化型低密度脂蛋白(ox-LDL)水平及颈动脉粥样硬化的关系。方法选取在我院行颈动脉彩色超声诊断为颈动脉粥样硬化的知情同意者129例,用14C尿素呼气试验检测入选对象的Hp感染情况,同时采用酶联免疫吸附法测定其血清ox-LDL水平,然后分析它们之间的关系。结果颈动脉粥样硬化患者Hp感染组血清ox-LDL、总胆固醇、低密度脂蛋白胆固醇、甘油三酯水平高于非Hp感染组,差异均具有统计学意义(P<0.05,P<0.01);随着颈动脉粥样硬化患者体内Hp感染程度的加重,其血清ox-LDL水平亦相应增高,F检验结果显示,不同Hp感染程度分组其血清ox-LDL水平差异具有统计学意义(F=13.169,P<0.01),且3组间两两比较,血清ox-LDL水平差异均具有统计学意义(P<0.05);多元线性回归分析显示,Hp感染者血清ox-LDL水平升高。结论幽门螺杆菌感染可能在一定程度上引起脂质代谢障碍,使血清ox-LDL水平升高,并因此加速颈动脉粥样硬化的进展。Aim To explore relationship between Helicobacter pylori（ Hp） infection and serum oxidized low density lipoprotein（ ox-LDL） in carotid artery atherosclerosis patients. Methods 129 cases with carotid atherosclerosis diagnosed by carotid artery ultrasonography in our hospital were chosen,14 C urea breath test was used to detect Hp infection situation of the selected object. Meanwhile enzyme-linked immunosorbent method is used to determine the serum levels of ox-LDL. Results Serum ox-LDL,total cholesterol（ TC）,low density lipoprotein cholesterol（ LDLC） and triglyceride（ TG） levels of patients with carotid atherosclerosis in Hp infection group were higher than that of Hp non-infection group,and the differences were statistically significant（ P 〈 0. 05,P 〈 0. 01）. With carotid atherosclerosis in patients with Hp infection in vivo degree aggravating,its serum ox-LDL level also increased accordingly. The differences of serum ox-LDL level in different degree of Hp infection groups were statistically significan（ F = 13. 169,P 〈 0. 01）,and pairwise comparisons among the three groups,serum ox-LDL level differences were statistically significant（ P 〈 0. 05）.Multiple linear regression analysis showed that serum levels of ox-LDL was significantly increased in Hp infected patients.Conclusion Helicobacter pylori infection may cause lipid metabolic disorders in a certain extent,increase serum levels of ox-LDL,and promote the development of the carotid atherosclerosis.

关 键 词：幽门螺杆菌 颈动脉粥样硬化 氧化型低密度脂蛋白 

分 类 号：R446.1[医药卫生—诊断学]