二甲双胍抗肺癌机制的研究进展  

Advance on mechanisms of metformin's anti-lung-cancer activity

作　　者：蒋永源 罗虎[1] 周向东[1] 

机构地区：[1]第三军医大学西南医院呼吸内科,重庆医学硕士400038

出　　处：《医学研究生学报》2014年第10期1114-1117,共4页Journal of Medical Postgraduates

摘　　要：糖尿病和肺癌均是世界范围内的常见病,严重影响人类身体健康。近年流行病学研究显示:糖尿病可能增加肺癌的发病率,是肺癌发生的危险因素之一。二甲双胍作为治疗糖尿病的一线药物,具有降低肺癌发病率的作用,同时其本身可能具有抗肿瘤活性,但其作用机制仍不清楚。深入研究二甲双胍的作用机制,有望降低糖尿病患者肺癌发病率,同时可为肺癌的临床治疗提供新的靶点。文中就二甲双胍抗肺癌的可能作用机制作一综述。Diabetes and lung cancer are common diseases worldwide , which have a serious impact on human health .Recently epidemiologic research has found that diabetes , which may enhance the incidence of lung cancer , is one of the risk factors of lung canc-er.The metformin, a first-line drug for treatment of type 2 diabetes, can decrease the incidence of lung cancer and may have an anti-lung-cancer bioactivity ,but its mechanisms are unclear .To make a further study of the mechanisms is expected to reduce the morbidity and is possible to help us find a new therapeutic target .The aim of this article is to review the potential mechanism of the metformin′s anti-lung-cancer activity .

关 键 词：二甲双胍 肺癌 作用机制 

分 类 号：R979.1[医药卫生—药品]