慢性鼻-鼻窦炎嗅觉障碍者嗅球体积的MRI初步研究  

Olfactory bulb magnetic resonance imaging in patients with chronic rhinosinusitis

作　　者：冯炜[1] 吴戈[2] 尹晓明[2] 

机构地区：[1]中国中医科学院望京医院耳鼻咽喉科,北京100102 [2]北京煤炭总医院影像科,北京100028

出　　处：《中国耳鼻咽喉头颈外科》2014年第9期473-476,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：北京煤炭总医院院级课题(10-15)

摘　　要：目的探讨慢性鼻-鼻窦炎(CRS)嗅觉障碍与嗅球体积的相关性。方法收集10例CRS嗅觉障碍患者,并以11例健康志愿者作对照,行MRI多个序列和方位检查,比较两组嗅球体积大小。结果 CRS患者的左右侧嗅球体积均值分别为(44.2±7.4)mm3和(44.3±5.8)mm3,健康志愿者的左右侧嗅球体积均值分别为(51.4±1.3)mm3和(50.6±1.5)mm3,两组差异均具有统计学意义(左:t=-3.19,P=0.0048;右:t=-3.52,P=0.0023)。按病程分亚组,长病程组(≥8年)嗅球体积均值小于短病程组(<8年),左侧:(38.0±3.5)mm3 vs(50.5±3.6)mm3,t=-5.51,P=0.0006;右侧:(39.1±2.2)mm3 vs(49.4±2.1)mm3,t=7.61,P<0.0001;短病程组与健康志愿者的左右侧嗅球体积均值均无差异(左:t=-0.8,P=0.4346;右:t=-1.32,P=0.2069)。结论 MRI对于病程较长的CRS伴嗅觉障碍者,有一定诊断意义。OBJECTIVE To explore the correlation between dysosmia and volume of olfactory bulb（OB） in patients with chronic rhinosinusitis（CRS）. METHODS Ten patients with CRS and 11 healthy volunteers were included in this study. OB volume was compared between CRS group and control group. RESULTS The mean OB volume in CRS group were（44.2±7.4）mm^3（left） and（44.3±5.8）mm^3（right）, while in control group were（51.4±1.3）mm^3（left） and（50.6±1.5）mm^3（right）. There was a significant statistical difference between the two groups in both sides（left： t=-3.19, P=0.0048; right： t=-3.52, P=0.0023）. The mean OB volume in patients with course of disease≥8 years were（38.0±3.5）mm^3（left） and（39.1±2.2）mm^3（right）, while in course of disease 〈8 years were（50.5±3.6）mm^3（left） and（49.4±2.1）mm^3（right）. Significant statistical differences were found between the two groups in both sides（left： t=-5.51, P=0.0006; right： t=7.61, P0.0001）. No statistical difference was found between the patient group（course of disease 8 years） and control group（left： t=-0.8, P=0.4346; right： t=-1.32, P=0.2069）. CONCLUSION The course of chronic rhinosinusitis patients with dysosmia is correlated with OB volume. There is no significant change of OB volume in patients with short course of disease. The longer the course of the disease, the more risk of shrinking volume of OB.

关 键 词：鼻窦炎 嗅觉障碍 嗅球 磁共振成像 摄影测量法 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]