microRNAs103和107与胰岛素抵抗的相关性研究  

Relationship between microRNA103 or 107 and insulin resistance

作　　者：徐倩[1] 李盈[1] 高珊[1] 张方华[1] 姚民秀[1] 

机构地区：[1]青岛大学医学院第二附属医院内分泌代谢科,266042

出　　处：《中国糖尿病杂志》2015年第1期37-39,共3页Chinese Journal of Diabetes

摘　　要：目的测定以IR为主的超重或肥胖T2DM患者血清microRNAs103和microRNAs107(miR-103/107)的表达水平,探究miR-103/107与IR的关系。方法选取超重或肥胖且IR的新诊断T2DM患者(IR组)50例及健康对照(NC)者30名,采用RT-PCR法测定血清miR-103/107的表达水平,同时检测FPG、FIns及TG,采用稳态模型评估胰岛素抵抗指数(HOMA-IR)。结果 (1)IR组血清miR-103/107的表达水平高于NC组[(5.77±0.82/8.84±1.04)vs(2.53±0.51/4.51±0.94),P<0.05];(2)Pearson相关分析显示,miR-103/107与HOMA-IR、TG及BMI呈正相关(P=0.010);(3)miR-103/107是IR的独立影响因素(β=0.430、0.054,P=0.016、0.010)。结论 miR-103/107参与IR的形成,可能作为治疗IR的靶点之一。Objective To determine the expression levels of serum microRNAs103 and 107（miR-103/107）in type 2diabetes mellitus with overweight or obesity,to study the relationship between miR-103/107 and insulin resistance. Methods 50 newly diagnosed T2 DM patients with overweight or obesity（IR group）and 30 healthy cases（NC group）were collected.The expression levels of miR-103and107 were detected by quantitative PCR.FPG,FIns and TG were measured.The basal insulin resistance（HOMA-IR）was evaluated by homeostatic model assessment. Results（1）The expression levels of serum miR-103/107 were higher in IR group than in NC group[（5.77±0.82/8.84±1.04）vs（2.53±0.51/4.51±0.94）,P0.05].（2）Pearson correlation analysis showed that miR-103/107 were positively correlated with HOMA-IR,TG and BMI（P=0.010）.（3）Multiple linear regression analysis showed that miR-103/107 were independently influencing factors of IR（β=0.430,0.054,P =0.016,0.010）.Conclusion miR-103 and 107involve in the insulin resistance and may be one of target points for the treatment of insulin resistance.

关 键 词：microRNAs103 microRNAs107 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]