糖尿病对环境危害因素的易感性特征及其机制的研究进展  

Research progress of the susceptibility of diabetes to environmental hazardous factors and its potential mechanisms

作　　者：李芳[1] 张凯[1] 王苏华[1] 陆荣柱[1] 邢光伟[1] 吴向阳[2] 董颖[1] 

机构地区：[1]江苏大学基础医学与医学技术学院卫生检验系,镇江212013 [2]江苏大学环境学院环境科学与工程系

出　　处：《中国糖尿病杂志》2015年第1期85-87,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81302459);中国博士后科学基金(2013M540424);江苏省博士后科学基金(13021516);江苏大学高级专业人才科研启动基金(13JD024)

摘　　要：糖尿病改变了患者对环境危害因素的易感性,主要表现在环境因素增加了糖尿病人群急性心脑血管并发症的发病率,降低了该人群的免疫力,并导致糖尿病人群的肺、肝、肾及神经等多系统损害比健康人群更严重。糖尿病对环境因素易感性改变的可能机制包括改变毒物代谢动力学规律、抑制组织代偿性修复能力、诱发氧化应激及扰乱机体炎症调节反应和凝血机制,但其确切的易感性特征及其机制有待进一步研究。Patients with diabetes have an enhanced susceptibility to environmental hazards.This review comprehensively addresses the patterns of increased susceptibility to pollutants and hazards in cardiovascular,pulmonary,liver,kidney and nervous systems. Furthermore,when exposing to environmental hazards,the immune system were severely damaged in individuals with diabetes.The mechanisms of the susceptibility are related to：（1）The toxicokinetics of environmental toxicants in subjects with diabetes are changed;（2）The compensatory capacity of tissue repair is inhibited;（3）Diabetes induces the oxidative stress;（4）Inflammatory and coagulation mechanisms also involved.The specific policy is warranted for protection of diabetes from environmental and occupational hazards,based on clarification of exact altitude of altered susceptibility and potential mechanisms in diabetes.

关 键 词：糖尿病 易感性 环境危害因素 健康损害 机制 

分 类 号：R587.1[医药卫生—内分泌]