盐城市婴幼儿手足口病发病强度及母传抗体降低易感性的研究  

Determination of mother preached antibody levels of EV71 and CVA16 in the newborn and evaluation of the influence on the HFMD susceptibility in Yancheng

作　　者：张红军[1] 姜仁杰[1] 陈树霞 杨志俊[3] 李长城[1] 徐士林[1] 梁季[1] 

机构地区：[1]江苏省盐城市疾病预防控制中心,江苏盐城224002 [2]盐城市第一人民医院,江苏盐城224000 [3]盐城出入境检验检疫局,江苏盐城224000

出　　处：《现代预防医学》2015年第4期640-642,662,共4页Modern Preventive Medicine

摘　　要：目的了解盐城市手足口病发病强度,测定新生儿EV71、CVA16的母传抗体水平,研究其对手足口病易感性的影响,为手足口病预防及制定疫苗使用策略提供理论依据。方法采集本市4个县（区）669名新生儿脐带血标本,进行EV71、CVA16中和抗体水平测定,2011年10月对队列儿童进行回顾性调查手足口病发病情况,统计不同年龄别发病率,分析母传抗体水平及其与手足口病发病的关系。结果盐城市0~、1~、2岁~儿童年龄别发病率分别为2.10%、6.43%和5.98%,0岁~组发病率最低,经卡方检验,组间差异有统计学意义,P〈0.05;EV71和CVA16母传抗体阳性率分别为21.97%和12.86%,EV71母传抗体水平高于CVA16母传抗体水平,经卡方检验,差异有统计学意义,P〈0.05。EV71母传抗体阴性组手足口病发病率为16.28%,阳性组为8.16%;EV71母传抗体阳性和阴性的12月内新生儿,EV71发病率分别为0.68%和2.49%,经卡方检验,差异均有统计学意义,P〈0.05。结论盐城市婴幼儿手足口病呈高强度流行,EV71母传抗体水平越高对于婴儿的保护性越强,1岁后保护性逐渐下降,12个月左右注射EV71手足口疫苗具有较好的保护性。Objective The aim of this study was to investigate the disease intensity of HFMD in Yancheng city, determine the mother preached antibody levels of EV71 and CVA16 in the newborn, and analyze the effect on the susceptibility of HFMD, in order to provide theoretical reference for utilization fo vaccines and HFMD prevention. Methods Umbilical cord blood samples from 669 neonatals were collected in four counties （district）, and the mother preached antibody levels of EV71 and CVA16 were determined by neutralizing antibody assay. Retrospective investigation was performed in October 2011. The incidence in different age statistically studied. The relationship between mother preached antibody levels and the incidence of HFMD were analyzed. Results The age-specific incidence of HFMD in 0-1, 1-2, and 2-3 years old children were 2.10%, 6.43% and 5.98%, respectively. The lowest incidence was found in 0-1 year old group. The difference between groups was statistically significant by chi-square test, P〈0.05. The positive rate of mother preached antibody levels of EV71 and CVA16 were 21.97% and 12.86%, respectively. The mother preached antibody levels of EVT/1 was higher than CVA 16, and the difference was statistically significant by chi-square test, P〈0.05. The incidence of HFMD for negative group of mother preached antibody of EVT1 was 16.28%, and that for the positive group was 8.16%. The incidence of HFMD in 12 months old baby for positive and negative group of EV71 mother preached antibody were 0.68% and 2.49%, respectively. The differences were statistically significant by the chi-square test, P〈0.05. Conclusion The prevalence of infants with HFMD in Yancheng city was high. The higher mother preached antibody level of EV71, the stronger protective effect was found in infants. When the infant was more than one year old, the protective effect gradually declined. And good protection can be achived by injecting EV71 vaccine at the age of 12 months or so.

关 键 词：手足口病 母传抗体 EV 71 CVA 16 

分 类 号：R174[医药卫生—妇幼卫生保健]