2009-2013年连云港市疑似预防接种异常反应监测分析  

Study on the Surveillance of Adverse Events Following Immunization in Lianyungang during 2009-2013

作　　者：谷利妞[1] 陈秀丽[1] 许雷[1] 

机构地区：[1]连云港市疾病预防控制中心,江苏连云港222003

出　　处：《现代预防医学》2015年第4期729-731,743,共4页Modern Preventive Medicine

摘　　要：目的分析连云港市疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价疫苗的安全性和预防接种服务质量。方法采用描述性流行病学方法对连云港市2009-2013年AFEI资料进行分析。结果 2009-2013年连云港共报告AEFI病例4 893例,报告发生率为3.87/万,其中一般反应和异常反应的报告发生率分别为3.49/万和0.37/万,未出现接种差错和疫苗质量事故;临床诊断以发热/红肿/硬结和过敏性反应为主;AEFI病例中无细胞百白破疫苗引起的AEFI构成比最高,占39.87%,男女性别比为1.63∶1,病例主要发生在≤1岁组人群,占67.32%;夏季(6-8月份)报告病例最多,占35.25%,冬季最少,占14.69%;82.77%的AEFI在接种后1d发生。结论连云港市AEFI监测系统运转正常,疫苗的安全性和预防接种服务质量良好,但在加强AEFI被动监测的同时,可探索性开展主动监测。Objective This study was to analyze the characteristics of adverse events following immunization （AEFI） in Lianyungang from 2009 to 2013. Methods Descriptive epidemiological analysis was conducted on the surveillance data of AEFI. Results 4893 AEFI cases were reported during 2009-2013, with a rate of 3.87/10 000. The common and rare vaccine reaction were 3.49/10 000 and 0.37/10 000, respectively. Vaccine quality event and error in vaccination were not reported. Fever, redness, scleroma and allergic reactions were the most common clinical symptoms. 39.87% of the cases were caused by DpaT. The ratio of male and female patients was 1.63：1. 67.32% of patients were ≤ 1 years old. 35.25% of cases occurred in summer （from June to August）, and 14.69% in winter. 82.77% of cases occurred within one day after vaccination. Conclusion The AEFI surveillance system works well, and the safety and quality of vaccination are satisfactory. However, it is still necessary to improve AEFI surveillance.

关 键 词：疑似预防接种异常反应 监测 评价 

分 类 号：R186[医药卫生—流行病学]