龙利叶水提物的止咳祛痰作用研究  

Study on the antitussive and expectorant effects of water extracts from Sauropus rostratus

作　　者：丁聪[1] 贺勤[2] 柳贤福[1] 

机构地区：[1]广西中医药大学赛恩斯新医药学院,广西南宁530001 [2]广西中医药大学药学院,广西南宁530001

出　　处：《华西药学杂志》2015年第1期49-50,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究壮药龙利叶水提物的止咳、祛痰作用及祛痰的最佳给药时间。方法采用氨水引咳法评价龙利叶水提物的止咳作用,采用小鼠酚红分泌法评价龙利叶水提物的祛痰作用以及辰时和亥时给药的祛痰效果的区别。结果龙利叶水提物低、中、高剂量(5、10、15 g·kg-1)均能有效抑制由氨水引发的小鼠咳嗽,增强小鼠酚红分泌量;在祛痰效果上,辰时和亥时给药与空白组比较有效,但两者间并无显著差异。结论龙利叶水提物对小鼠由氨水引发的咳嗽有较好的抑制作用;对小鼠的酚红分泌有较显著的作用,且辰时和亥时给药均有疗效。OBJECTIVE To investigate the antitussive and expectorant effects of the water extracts from Zhuang herb Sauropus rostratus Miq. , and the best time for administration. METHODS The method of cough induced by ammonia solutions was used to study the antitussive effect, and the method of phenol red excretion in mice to study the expectorant effect of the water extracts from S. rostratus ,respectively, and the best time to take medicine. RESULTS Water extracts from S. rostratus high dose group （5 g·kg^-1） ,middle dose group（ 10 g·kg^-1） and low dose group（ 15 g·kg^-1） all could inhibit the cough induced by ammonia water and increased the phenol red excretion in the mice. In the expectorant effect,comparing taking medicine at the period of the day from 7：00 to 9：00 and 21：00 to 23：00, two groups all had significant expectorant effect, but there was no difference between each group. CONCLUSION Water extracts from S. rostratus has significant antitussive effect to inhibit the cough induced by ammonia solution, also has significant expectorant effect to increase the phenol red excretion in mice. And there is no difference between taking medicine at the period of the day from 7：00 to 9：00 and 21：00 to 23：00.

关 键 词：龙利叶水提物 止咳 祛痰 时辰给药 氨水引咳法 

分 类 号：R96[医药卫生—药理学]