冠心病中医证型与血浆vWF、Ps、hs-CRP、FIB、TXB_2、6-keto-PG_(1α)关系的临床研究  

Clinical Research on Expression of v WF,Ps,hs-CRP,FIB,TXB_2,6-keto-PGF_(1α) of Differential TCM Syndrome of Coronary Heart Disease

作　　者：顼志兵[1] 汪卫东[1] 张莉芬[1] 李俊[1] 王毅[1] 奚希相[1] 朱杰[1] 马金苗 贾晶莹[2] 张丽葳[1] 顾仁樾[3] 

机构地区：[1]上海市第七人民医院急诊科,上海200137 [2]上海市徐汇区中心医院实验中心,上海200031 [3]上海中医药大学附属龙华医院心内科,上海200032

出　　处：《中国中医基础医学杂志》2015年第1期66-68,79,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：山西省科技项目(0410789-1)-血浆同型半胱氨酸与冠心病中医证型的关系及致病机制研究;上海市教委资助项目(06CZ021)-银杏叶对高同型半胱氨酸血症内皮功能受损的干预作用及其机制实验研究

摘　　要：目的:探讨血浆v WF、Ps、hs-CRP、FIB、TXB2、6-keto-PGF1α与冠心病中医证型的关系。方法:将152例冠心病患者辨证分为心血瘀阻、痰阻心脉、阴寒凝滞、心肾阴虚、气阴两虚、阳气虚衰,测定血浆v WF、Ps、hs-CRP、FIB、TXB2、6-keto-PGF1α值。结果:心血瘀阻、痰阻心脉、心肾阴虚、气阴两虚4型血浆v WF、Ps、FIB、TXB2水平明显升高,心血瘀阻、痰阻心脉2型高于心肾阴虚、气阴两虚2型,心血瘀阻、痰阻心脉、心肾阴虚、气阴两虚4型血浆6-keto-PGF1α水平明显降低,心肾阴虚、气阴两虚证型2型低于心血瘀阻和痰阻心脉2型。各证型血浆hs-CRP水平比较差异无统计学意义。结论:提示心肾阴虚、气阴两虚两型病机为炎症损伤血管内皮,心血瘀阻、痰阻心脉是炎症损伤血管内皮基础上,抗血栓能力下降,导致动脉粥样硬化。Objectives： To study relationship betweedrome types of coronary heart disease （CHD） and plasma vWF （ yon willebrand ＇ s factor）, Ps （ P-selectRP （ hight-sensitivity C-reactive protein ）, TXB2 （thromboxane B2 ）, 6-keto-PGF1α （6-keto-prostaglandin）, and guide the treatment based on syndrome differentiation of CHD. Methods： The patients with CHD w into 6 groups, such as stagnation of heart vessel, retention of phlegm in heart vessel, stagnation of qi due to dcieney of heart and kidney, deficieney of both qi and yin, deficieney of both yang and qi. Levels of plasma vWIRP,FIB, TXB2 , 6-keto-PGF1α were determinated. Results： Plasma vWF, Ps, FIB, TXB2 , hs-CRP levels of ）f heart vessel group, retention of phlegm in heart vessel group, yin deficieney of heart and kidney group, deboth qi and yin group were significantly higher than that of control group respectively. Plasma 6-keto-PGF1α levour groups were also significantly lower than that of control group. Plasma vWF. Ps. FIB, TXB2 levels of stagnat vessel group, retention of phlegm in heart vessel group were statistically higher than those of yin deficieney kidney group, deficieney of both qi and yin group. Plasma 6-keto-PGF1α levels of yin deficieney of heart agroup, deficieney of both qi and yin group were significantly lower than those of stagnation of heart vessel lition of phlegm in heart vessel group. There was no statistical difference of plasma hs-CRP of four groups respeclusion ： Two type of deficiency of both qi and yin of heart and kidney is primarily by endothelial cell function in y injury, blood stagnation and phlegm blocking heart vessel is based on the inflammatory injury of endothelial celthe antithrombotic capability of Ecs and promote the extent of atherosclerosis.

关 键 词：冠心病 中医证型 P-选择素 冯维尔布兰德因子 高敏C反应蛋白 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]