和肽素对AECOPD患者的病情严重程度及生活质量评估的价值  

Clinical value of copeptin in severity and the evaluation of quality of life for the exacerbation of chronic obstructive pulmonary disease

作　　者：张琴琴[1] 许德凤[2] 刘锦铭[3] 赵雷[2] 赵云峰[2] 曹帆帆[2] 

机构地区：[1]宁夏医科大学全科医学,银川750021 [2]上海市浦东新区公利医院呼吸内科,200135 [3]同济大学附属上海市肺科医院肺循环科,200433

出　　处：《国际呼吸杂志》2015年第1期25-29,共5页International Journal of Respiration

基　　金：2013年上海市浦东新区卫生局卫生（计生）科技项目（PW2013A-29）

摘　　要：目的 分析血清和肽素对慢性阻塞性肺疾病急性加重期（AECOPD）患者病情严重程度及生活质量评估的意义。方法 对收治入院的150例AECOPD患者进行治疗前后血清和肽素、降钙素原、C反应蛋白的检测,并分析血清和肽素、降钙素原、C反应蛋白与COPD严重程度的关系及CAT评分,6分钟步行距离（6MWD）的相关性。结果 ①AECOPD治疗前血清和肽素、降钙素原、C反应蛋白显著高于治疗后和正常对照组（t=4.798,Z =-6.356,Z =-7.492,P 值均〈0.01）,AECOPD治疗后患者的血清和肽素、降钙素原、C反应蛋白均高于正常对照组（t=4.809,Z =-5.415,Z =-4.495,P 值均〈0.01）,且在一定程度上随着病情严重程度的增加而增加;②和肽素水平与患者生活质量评估表（CAT）呈正相关（r =0.336,P =0.000）;与运动能力评估指标6WMD 呈负相关（r =-0.350,P =0.000）。结论 血清和肽素水平在一定程度上可以反映AECOPD患者病情严重程度,对患者的生活质量评估具有一定的临床价值.Objective To analyse the severity of disease and the evaluation of serum quality of life value of serum copeptin in the patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods The serumal copeptin, procalcitonin, C-reactive protein were detected in 150 hospitalized AECOPD patients before and after the treatment. And to study the correlation above indexs with chronic obstructive pulmonary disease （COPD） severity and the COPD assessment test （CAT）, 6 minutes walk distance （6MWD）. Results Compared with after the treatment patients and healthy control group, serumal levels of the copeptin, procalcitonin, C-reactive protein were significantly elevated in the patient with AECOPD before the treatment （ t =4. 798, Z =-6. 356, Z =-7. 492, P 〈0.01）. Above indexes were significantly higher at after the treatment patients than healthy control group （ t =4. 809, Z =-5. 415, Z =-4. 495, P 〈0.01）. To a certain extent, the level of these indicators were increasing with the increase in the severity of the disease. The serumal copeptin were positively correlated with CAT （ r = 0. 336, P = 0. 000）,and were negatively correlated with 6MWD （ r =-0. 350, P = 0. 000）. Conclusions Serum copeptin can reflect the severity of AECOPD patients in a certain extent,and has certain clinical value to evaluate the quality of life in patients.

关 键 词：慢性阻塞性肺疾病急性加重期 和肽素 降钙素原 C反应蛋白 CAT评分量表 6分钟步行实验 

分 类 号：R563.9[医药卫生—呼吸系统]