透明质酸酶治疗透明质酸填充过度的疗效观察  

Effect of hyaluronidase on treating overcorrection with hyaluronic acid

作　　者：张元文[1] 徐军[2] 晏晓青 曾玮[2] 王白石[2] 潘文东[1] 

机构地区：[1]解放军第五十九中心医院烧伤整形外科,云南开远661600 [2]解放军总医院整形修复科 [3]北京伊美尔幸福医学美容专科医院

出　　处：《中国美容整形外科杂志》2015年第1期9-12,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的 探讨应用透明质酸酶治疗透明质酸过度填充引起填充物积贮而导致局部出现皮下肿块或硬结的有效性及安全性.方法 对自2010年3月至2013年3月收治的25例因透明质酸面部注射填充过度致局部不美观患者的临床资料、治疗方法和随访资料进行总结分析.结果 25例患者注射透明质酸酶后24 ～48 h,皮下肿块或硬结均明显缩小或消失,其中2例出现短暂性局部过敏反应,未特殊治疗,24 h内症状消失.结论 采用透明质酸酶治疗透明质酸填充过度敛皮下肿块或硬结,疗效满意,无严重的不良反应发生.Objective To investigate the effect of hyaluronidase on subcutaneous lump or sclerosis caused by overcorrection with hyaluronic acid （HA）. Methods Clinical data, therapeutic methods and followup data about 25 inaesthetie patients with HA overeorrection from March 2010 to March 2013 were performed retrospective analysis and summary. Results The subcutaneous lumps or sclerosis on all 25 patients decreased or disappeared obviously at 24 ~ 48 hours after HA injection. Temporarily local allergic responses with hyaluronidase were occurred in 2 of 25 patients, which disappeared within 24 hours without any treatments. Conclusion Application of hyaluronidase in treatment of subcutaneous lump or sclerosis caused by overcorrection with hyaluronic acid is satisfactory without serious adverse reactions.

关 键 词：透明质酸酶 透明质酸 皮肤填充剂 并发症 

分 类 号：R622[医药卫生—整形外科]