人参药性菌质正丁醇部位化学成分(Ⅰ)  

Chemical Constituents of n-butanol Extract of Ginseng Medicinal Fungal Substance

作　　者：王明蛟 丁彩凤 刚婉娇 高航[2] 徐伟[1] 

机构地区：[1]长春中医药大学,长春130117 [2]吉林财经大学医院,长春130117

出　　处：《中国实验方剂学杂志》2015年第3期34-36,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科技发展计划项目(20130522047JH)

摘　　要：目的:对人参药性菌质中正丁醇部位化学成分进行研究,阐明其药效物质基础。方法:采用薄层色谱、硅胶柱色谱、Sephadex LH-20凝胶色谱、半制备液相等方法进行分离纯化,通过波谱数据和理化常数鉴定其化合物结构。结果:从人参药性菌质正丁醇部位中分离并鉴定得到5个化合物,分别为20(S)-人参皂苷-Rg2(1),20(R)-人参皂苷-Rg2(2),人参皂苷Rg1(3),20(S)-人参皂苷Rf(4),人参皂苷Rb1(5)。结论:所有化合物均为首次从人参药性菌质中分离得到。Objective ： To investigate the chemical constituents of n-butanol extract of Ginseng medicinal fungal substance, which was to clarify the basis of its efficacy substance. Method： Thin-layer chromatography, column chromatography on silica gel, Sephadex LH-20 gel chromatography, semi-preparative liquid chromatography were used for the isolation and purification of the compounds and their structures were determined by comparison of their chromatographic and spectral data with those of the authentic samples and those reported in the literature. Result ： Five compounds from n-butanol extract of ginseng medicinal fungal substance were identified as 20 （S） - ginsenosides-Rg2 （1） , 20 （R） -Ginsenosides-Rg2 （2） , Ginsenosides-Rgi （3） , 20 （S） -Ginsenosides-Rf （4） , ginsenosides-Rb1 （5）. Conclusion： All compounds are isolated from ginseng medicinal fungal substance for the first time.

关 键 词：人参皂苷 正丁醇 化学成分 

分 类 号：R284.1[医药卫生—中药学]