基于文献分析的“中药复方干预痴呆动物模型”研究规律及其发展现状  

Chinese Herbal Formula Intervention on Alzheimer Animal Model Systematic Review Based on Documental Analysis

作　　者：侯雪芹[1] 魏仁荣[1] 张玉[1] 高文斌[1] 闫蓉[1] 王奇[1] 

机构地区：[1]广州中医药大学,广州510405

出　　处：《中国实验方剂学杂志》2015年第3期201-204,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81273817);高等学校博士学科点专项科研基金项目(20134425110003);广东省重大科技专项(2012A080202017);广东省自然科学基金项目(S2012040006514);广东省高等学校科技创新项目(2012KJCX0032);广州中医药大学中医内科学特色重点学科建设项目

摘　　要：目的:系统分析"中药复方干预痴呆动物模型"相关文献,为进一步提高中药复方治疗老年性痴呆的研究提供实验基础。方法:系统整理近10年CNKI,VIP,万方和Pub Med数据库中关于中药复方干预用于老年性痴呆的动物实验研究。按纳入与排除标准筛选文献、提取资料后,分析中药复方的组方大小对其疗效结局、作用机制和资源消耗等的影响。结果:中药大复方与中药小复方在AD动物模型上具有相似的疗效结局,而大复方未表现出其在作用机制、资源消耗等方面的优势。结论:有必要优化抗老年性痴呆中药复方的配伍,提高其整体优势和研究价值。Objective： To provide evidence for further researches through systematicly reviewing and analyzing the literatures about Chinese herbal formula intervention on Alzheimer animal models. Method： Animal experiments on Alzheimer＇ s disease using Chinese herbal formula were collected from China National Knowledge Infrastructure （CNKI）, VIP, Wanfang and the Pubmed database in recent 10 years. Literature searching and screening, were conducted according to inclusion and exclusion criteria. Then the influence on outcome, pharmacologic mechanisms and resource consumption with different number herbs formulas was analysed. Result： Formulas with more kinds of herbs showed no advantage on efficacy, pharmacologic mechanisms and resource consumption than formulas with few kinds. Conclusion： It＇s necessary to optimize the compatibility of Chinese herbal formula in treating Alzheimer＇s disease, which would exhibt the overall advantages and increase the research values of Chinese herbs.

关 键 词：老年性痴呆 中药复方 动物实验 研究现状 

分 类 号：R287[医药卫生—中药学] R285.5[医药卫生—中医学]