活化Th17细胞的命运归宿  

Fate of activated Th17 cells beyond apoptosis and memory

作　　者：张梦洁[1] 杨爽[1,2] 田易[1] 

机构地区：[1]第三军医大学全军免疫学研究所,重庆400038 [2]贵州省遵义县人民医院内科,遵义563100

出　　处：《免疫学杂志》2015年第1期84-86,共3页Immunological Journal

基　　金：国家自然科学基金(31070798,31200668);“973”项目(2013CB531503)

摘　　要：记忆应答是免疫系统的一个典型特征。虽然CD8+T记忆细胞的作用及其形成机制目前比较清楚,但是由于CD4+T细胞的异质性,使记忆CD4+T细胞与CD8+T记忆T细胞之间存在显著差异。CD4+T细胞新亚群——Th17细胞活化后,除了和CD8+T细胞一样会分化为记忆Th17细胞或者凋亡,还可以变成表达IFN-γ细胞或表达IL-10的抑制性Th17细胞或有直接被排到肠腔而被清除。本文对这些研究现状的形成机制最新研究进展进行综述和讨论。Memory responses represent a defining feature of the immune system. It has been well elucidated for the biology and functions of CD8＋T memory T cells to date, however, the biology of memory CD4＋T cells is very different from CD8＋T cells due to the apparent heterogenicity of CD4＋T cells and thus remains to be clarified.Similar to CD8＋T cells, the activated Th17 cells might undergo the apoptosis or convert to the memory cells.However, the activated Th17 cells could converted to IFN-γ-expressing T cells or IL-10-expressing Th17 cells, or be excluded into the gut lumen. In this review, we analyze and discuss the latest progress of the studies on the fate of activated Th17 cells.

关 键 词：TH17 IL-23 RORΓT 免疫记忆 

分 类 号：R392[医药卫生—免疫学]