针刺“宁心安神”抗焦虑的A型利钠肽受体机制探讨  

Mechanism on atrial natriuretic peptide receptor in anti-anxiety with acupuncture based on its tranquilizing effect

作　　者：何薇[1] 周奇志[1] 余曙光[1] 蔡定均[1] 王强[1] 张潇丹[1] 黄文琴[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《中国针灸》2015年第1期101-104,共4页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金项目:81173322;教育部博士点基金博导类课题项目:20135132110009

摘　　要：焦虑障碍是最常见的精神疾病之一,严重危害患者的身心健康。针刺因有"宁心安神"功效而对焦虑障碍的治疗独具优势,但有关生物学机制尚未阐明。现代医学研究已证实,心、脑存在两个独立的利钠肽系统。A型利钠肽及其受体功能失调与焦虑障碍的产生密切相关,A型利钠肽具有抗焦虑活性。基于此,拟从针刺"宁心安神"抗焦虑效应、A型利钠肽抗焦虑作用、针刺对利钠肽的良性调节作用三方面入手,探讨针刺"宁心安神"抗焦虑效应的利钠肽及其受体调节机制,提出"针刺抗焦虑可能是通过调节A型利钠肽及其受体而发挥‘宁心安神’作用"的观点,以期为开展针刺"宁心安神"抗焦虑作用的机制研究提供理论支持。Anxiety disorder is one of the most common mental disorders and seriously impairs the physical and mental health of patients. Due to the efficacy of acupuncture for tranquilization, acupuncture displays its unique advantage on the treatment of anxiety disorder, but the relevant biological mechanism has not been elaborated. The modern medicine study has proved that the heart and brain have their own independent natriuretic peptide （NP） system. The dysfunction of ANP and its receptor are closely related to the occurrence of anxiety disorder. The ANP acts on anti-anxiety. Hence, focusing on the three aspects, named the anti-anxiety effect of acupuncture based on its tranquilizing effect, the anti-anxiety effect of ANP and the positive regulation of acupuncture on NP, the mechanism on ANP and its receptor was explored in anti-anxiety with acupuncture based on tranquilizing effect, and the idea was put forward on that the anti-anxiety effect of acupuncture was possibly based on its action of tranquilization through regulating the ANP and its receptor. As a result, it is expected to provide the theoretic support for the mechanism study on anti-anxiety with acupuncture based on its tranquilizing effect.

关 键 词：焦虑障碍 针刺 宁心安神 A型利钠肽 

分 类 号：R245[医药卫生—针灸推拿学]