ST段抬高性急性心肌梗塞患者循环血管内皮祖细胞与血管内皮生长因子及心功能的关系及意义  

Study on the correlation of circulating endothelial progenitor cells,vascular endothelial growth factor and cardiac function in patients with ST segment elevation myocardial infarction

作　　者：周学才[1] 

机构地区：[1]湖北省仙桃市第一人民医院心血管内科,湖北仙桃433000

出　　处：《海南医学院学报》2015年第3期329-331,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(11221665)~~

摘　　要：目的：研究ST段抬高性急性心肌梗塞（STEMI）患者循环血管内皮祖细胞与血管内皮生长因子及心功能的关系。方法：选取本院心内科行冠状动脉造影确诊STEMI患者124例,收集一般临床资料,并检测其就诊时循环血管内皮祖细胞与血管内皮生长因子,并进行分析。结果：血管内皮祖细胞、血管内皮生长因子进行Pearson相关性分析,表明血管内皮祖细胞与VEGF水平呈正相关（r=0.0057,P=0.001）。病程6-12h循环血管内皮祖细胞与血管内皮生长因子高于病程〈6h分层组患者,差异均有统计学意义（P〈0.05）;病程12-24h循环血管内皮祖细胞与血管内皮生长因子高于病程6-12h分层组,差异均有统计学意义（P〈0.05）;按照不同心功能Killip分级患者循环血管内皮祖细胞与血管内皮生长因子从高到低依次为：KillipⅡ级〉KillipⅢ级〉KillipⅠ级〉KillipⅣ级,差异均具有统计学意义（P〈0.05）。结论：STEMI患者血管内皮祖细胞与VEGF呈正相关,合严重心功能不全时导致的循环障碍可能减缓VEGF分泌与CEPCs归巢激活。Objective： To explore the correlation of circulating endothelial progenitor cells（CEPCs）, vascular endotheli- al growth factor（VEGF） in patients and cardiac function with ST segment elevation myocardial infarction（STEMI）. Methods： From January 2013 to June 2014, 124 cases of STEMI were recruited and clinical data was collected. CEPCs, VEGF were de tected and analyzed. Results： In cases of STEMI , the CEPCs rate and VEGF level results in positive correlation（r=0. 0057 ,P =0. 001）. The CEPCs rate and VEGF level showed gradual elevation within 24h（P〈0.05） ,and then reached a relative plat- form after 24h. According to Killip stage of cardiac function,the descending order of CEPCs rate and VEGF level was Killip Ⅱ stage〉Killip Ⅲ stage 〉 Killip Ⅰ stage 〉 Killip Ⅳ stage. Conclusion： In STEMI, CEPCs rate was positively correlated with VEGF level. And severe cardiac dysfunction may interfere with VEGF secretion and CEPCs homing.

关 键 词：冠心病 ST段抬高性急性心肌梗塞 环血管内皮祖细胞 血管内皮生长因子 

分 类 号：R542.2[医药卫生—心血管疾病]