穿心莲总内酯亲水凝胶骨架片的制备及体外释药机制研究  

Preparation of hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata and study on its in vitro release mechanism

作　　者：徐芳芳[1,2] 石伟[1,3] 张晖[2,3] 郭庆明[2,3] 王振中[2,3] 毕宇安[2,3] 王智民[3] 萧伟[2,3] 

机构地区：[1]南京中医药大学,江苏南京210000 [2]江苏康缘药业股份有限公司,江苏连云港222001 [3]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中国中药杂志》2015年第1期79-83,共5页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2012CB724001)

摘　　要：该实验研究了穿心莲总内酯骨架片的处方工艺及其体外释药行为。通过单因素试验,以不同型号及用量的羟丙甲基纤维素(HPMC)为主要考察因素,以3种内酯成分累积释放度为评价指标,优选出最佳处方,所制缓释片无突释现象,缓释周期14 h。采用零级、一级、Higuchi及Peppas方程判断穿心莲3种内酯类成分的释药机制,结果表明总内酯释放行为符合Higuchi模型,释放机制为骨架溶蚀机制。该法制备的穿心莲总内酯骨架片制备工艺简单易行,具有良好的释放性能。In this study, hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata were prepared and the in vitro release behavior were also evaluated. The optimal prescription was achieved by studying the main factor of the type and amount of hydroxypropyl methylcellulose （HPMC） using single factor test and evaluating through cumulative release of three lactones. No burst drug release from the obtained matrix tablets was observed. Drug release sustained to 14 h. The release mechanism of three lactones from A. paniculata was accessed by zero-order, first-order, Higuchi and Peppas equation. The release behavior of total lac- tones from A. paniculata was better agreed with Higuchi model and the drug release from the tablets was controlled by degradation of the matrix. The preparation of hydrophilic matrix sustained release tablets of total lactones from A. paniculata with good performance of drug release was simple.

关 键 词：穿心莲 总内酯 缓释片 制备 释放 

分 类 号：R283.6[医药卫生—中药学] R285[医药卫生—中医学]