寻常型天疱疮患者血清骨桥蛋白的检测  

Detection of serum osteopontin in patients with pemphigus vulgaris

作　　者：索桂英[1,2] 付萍[1] 

机构地区：[1]昆明医科大学第二附属医院皮肤/风湿免疫科,650101 [2]山东省淄博市中西医结合医院,255026

出　　处：《中华皮肤科杂志》2015年第1期53-54,共2页Chinese Journal of Dermatology

摘　　要：目的 探讨寻常型天疱疮（PV）患者血清中骨桥蛋白在PV发病中的作用.方法 用酶联免疫吸附试验对31例寻常型天疱疮患者和35例健康对照组血清骨桥蛋白的浓度进行测定.用SPSS17.0及Excell统计软件对数据进行处理.结果 PV患者血清骨桥蛋白的表达水平显著高于健康对照组（P＜0.01）.皮肤黏膜同时受累患者血清骨桥蛋白水平高于仅皮肤受累组（P＜0.05）.合并感染组血清骨桥蛋白水平高于未合并感染组（P＜ 0.01）; PV患者的血清骨桥蛋白水平与抗Dsg3抗体呈正相关（rs=0.489,P＜ 0.01）.结论 骨桥蛋白在PV患者血清中高表达,特别是皮肤黏膜同时受累的患者,且与天疱疮抗体滴度呈正相关.Objective To investigate the role of serum osteopontin in the occurrence of pemphigus vulgaris （PV）.Methods Enzyme-linked immunosorbent assay was conducted to determine serum levels of osteopontin in 31 patients with PV and 35 healthy human controls.Statistical analysis was carried out by t test and Spearman rank correlation analysis with the SPSS 17.0 software and Excel.Results Serum levels of osteopontin were significandy higher in patients with PV than in healthy controls （P 〈 0.01）,in patients with mucocutaneous involvement than in those with only cutaneous involvement （P 〈 0.05）,and in patients with complicated infections than in those without （P 〈 0.01）.There was a positive correlation between serum levels of osteopontin and anti-Dsg3 antibody in patients with PV （rs =0.489,P 〈 0.01）.Conclusions Serum levels of osteopontin are increased in patients with PV,especially in those with mucocutaneous involvement,and positively correlated with PV-related antibody titers.

关 键 词：天疱疮 骨桥蛋白 酶联免疫吸附测定 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]