H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells  

作　　者：Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang 

机构地区：[1]Biodynamic Optical Imaging Center (BIOPIC) [2]College of Engineering, [3]School of Life Sciences, Peking University, Beijing 100871, China

出　　处：《Cell Research》2015年第1期143-147,共5页细胞研究（英文版）

基　　金：We thank Prof Azim Surani for kindly giving us the mEpiSC cell line, and thank Tao Chen, Dr Yongfan Men, Zhilong Yu, Zitian Chen, Dr Liang Zhao, Haiwei Qiu, Lu Yang and Dr Yun Zhang for discussion and experimental help. This work was supported by the Ministry of Science and Technology of China （2011CB809106, 2012CB966704） and the National Natural Science Foundation of China （21222501, 21327808, 31271543, 91313302）. AMS was supported by the Whitaker International Biomedical Engineering Fellowship.

摘　　要：Dear Editor, Epigenetic regulation is crucial to the establishment and maintenance of the identity of a cell. Recent stud- ies suggest that transcription is implemented amongst a mixture of various histone modifications [1]. It has also been recognized that to interrogate function of genetic information, comprehensively systematic profiling of the epigenome in multiple cell stages and types is required [2].

关 键 词：胚胎细胞 表观 景观 早期 小鼠 芯片 组蛋白修饰 遗传调控 

分 类 号：Q959.837[生物学—动物学] S814.8[农业科学—畜牧学]