神经梅毒合并HIV感染6例分析  

Analysis of Six Cases of Neurosyphilis with HIV Infection

作　　者：魏春波[1] 魏连贵[2] 徐云良[2] 吴焱[1] 伦文辉[1] 

机构地区：[1]首都医科大学附属北京地坛医院皮肤性病科,北京100015 [2]首都医科大学附属北京地坛医院放射科,北京100015

出　　处：《中国皮肤性病学杂志》2015年第1期56-57,78,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨神经梅毒合并HIV感染的临床表现及转归。方法对北京地坛医院收治的6例神经梅毒合并HIV感染者的性别、好发人群、临床表现、实验室检查、诊断方法、治疗经过及转归进行回顾性分析。结果 6例神经梅毒合并HIV感染的患者,5例为男性同性恋者。除1例因青霉素过敏而失访外,其他5例患者对青霉素治疗均反应良好。结论男性同性恋人群是梅毒和HIV共感染的高危人群,临床表现多样,可以迅速进展到神经梅毒,且极易被误诊。临床上主要依靠梅毒血清学试验、脑脊液检查、影像学检查和全面细致的查体进行诊断。目前青霉素仍为首选治疗药物。Objective To investigate the manifestations and prognosis of neurosyphilis with HIV infection. Methods Padtients diagnosed as having HIV and neurosyphilis in Beijing Ditan Hospital were retrospectively studyed. Their demographic data, clinical manifestations, laboratory examination, treatment and follow-up results were analyzed. Results Five cases were male homosexuals in 6 cases of patients diagnosed as neurosyphiiis and HIV infection,5 patients responded well to penicillin other than one case lost because of penicillin allergy. Conclusion Male homosexual population is syphilis and HIV co-infection in high-risk groups. Clinical manifestations varied which easily were misdiagnosed and quickly progress to neurosyphilis are the features in syphilis patients with HIV infection. Diagnosis of neurosyphilis is also generally made with serology, cerebro- spinal fluid examination, imaging studies and a comprehensive and detailed examination, and so forth in HIV- positive patients. Penicillin-based regimen is still currently the preferable in neurosyphllis treatment.

关 键 词：人类免疫缺陷病毒 神经梅毒 合并感染 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R512.91[医药卫生—临床医学]