732强酸性阳离子树脂催化合成盐酸维生素B1  

Synthesis of Thiamine Hydrochloride Catalyzed by 732 Strong Acid Cation Exchange Resin

作　　者：白跃飞 皮昌桥 韩晓丹 刘丹 刘九知 于河舟 周凯 

机构地区：[1]东北制药集团股份有限公司,辽宁沈阳110027

出　　处：《合成化学》2015年第2期164-166,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以硫羟硫胺为原料,经双氧水氧化得硫酸维生素B1(VB1·H2SO4);VB1·H2SO4经纯化水稀释后,流经732强酸型阳离子交换树脂,用稀盐酸洗脱,浓缩后用85%乙醇重结晶得盐酸VB1,其结构经1H NMR,13C NMR,MS和元素分析确证。Thiamine sulfuric acid was synthesized by oxidation of hydrogen peroxide. Thiamine hydrochloride was synthesized by dilution of thiamine sulfuric acid with purified water,then flowing through 732 strong acid cation exchange resin in column,eluting with dilute hydrochloric acid,concentration and crystallization in 85% alcohol. The structure was confirmed by1 H NMR,13 C NMR,MS and elemental analysis.

关 键 词：维生素B1 732强酸型阳离子交换树脂 催化 合成 

分 类 号：O626[理学—有机化学]