左乙拉西坦杂质的合成  

Synthesis of Impurities in Levetiracetam

作　　者：陆骁骏 邹江 黄建金 杨琰 

机构地区：[1]华润赛科药业有限责任公司,北京100021

出　　处：《合成化学》2015年第2期179-181,共3页Chinese Journal of Synthetic Chemistry

基　　金：北京市朝阳区科技计划项目

摘　　要：分别以D-氨基丁酸和DL-氨基丁酸为起始原料,经4步反应合成了右乙拉西坦和左乙拉西坦杂质A——(S)-N-(1-氨基-1-氧代丁基)-4-氯丁酰胺(纯度97.0%);左乙拉西坦经水解反应合成了左乙拉西坦酸(纯度99.9%),其结构经1H NMR和MS确证。（R）-Levetiracetam and（S）-N-（1-amino-1-oxobutan-2-yl）-5-chloropentanamide with the purity of 97. 0% were synthesized by a four-step reaction from D-2-aminobutyric acid or 2-aminobutyric acid,respectively.（R）-α-ethyl-2-oxo-1-pyrrolidineacetic acid with the purity of 99. 9% was synthesized by hydrolysis of（S）-Levetiracetam. The structures were confirmed by^1 H NMR and MS.

关 键 词：左乙拉西坦 杂质 合成 

分 类 号：O626.1[理学—有机化学] R914.5[理学—化学]