柳氮磺胺吡啶及美沙拉嗪对溃疡性结肠炎结肠黏膜RegIV蛋白表达的影响及意义  

作　　者：朱春霞[1] 秦丽君[1] 

机构地区：[1]浙江省宁波大学医学院附属医院,315020

出　　处：《浙江临床医学》2015年第1期7-8,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨柳氮磺吡啶（SASP）及美沙拉嗪对溃疡性结肠炎结肠黏膜RegIV蛋白表达的影响及意义。方法收集溃疡性结肠炎患者60例，分成SASP组（A组）和美沙拉嗪组（B组），随访及治疗8NN复查肠镜及黏膜活检，通过RT-PCR、免疫组化检测RegⅣ表达水平。结果RT-PCR、免疫组化结果提示RegIV在两组治疗前表达差异无统计学意义（P〉0．05）；治疗后两组表达均明显下降，差异有统计学意义（P〈0．05）；美沙拉嗪组下降水平〉SASP组（P〈0．05）；RegⅣ表达水平与溃疡性结肠炎活动度呈正相关（r=0．872，P〈0．001）。结论美沙拉嗪较柳氮磺胺吡啶对RegⅣ有更强的抑制作用。Objective To explore the effects of sulfasalzine and mesalazine on the expression of Reg IV in mucosa with ulcerative colitis and its significance. Methods Sixty patients with ulcerative colitis were included in the study, they were randomized in Sulfasalzine and Mesalazine therapy groups, 8 weeks after two kinds of therapy, they were undergone colonoscopy examination and mucosa biopsy, Reg Ⅳ expression was investigated by RT-PCR and Immunohistochemical staining. Results RT-PCR and immunohistochemistrical staining for Reg Ⅳ after the therapy in the mucosa was significantly lower than that before the therapy in ulcerative colitis （ P〈0.05 ） . Mesalazine therapy group significantly decreased Reg Ⅳ level than Sulfasalzine therapy group. There was a positive correlation between Reg Ⅳ and CAI （ the colitis activity index ） expression in UC （ r = 0.872, P〈0.001 ） . Conclusion Mesalazine significantly inhibits Reg IV levels than Sulfasalzine.

关 键 词：溃疡性结肠炎 RegⅣ 柳氮磺胺吡啶 美沙拉嗪 

分 类 号：R259.746.2[医药卫生—中西医结合]