哮喘患儿发作与缓解期血清IL-4及IgE水平变化及意义  

Changes and Significance of Serum IL-4 and Ig E Levels in Acute Attack Asthma and Remission Period

作　　者：黄璧璇 许新连 林苑琪[2] 徐桂萍[2] 侯元婕[2] 

机构地区：[1]广东省惠州市第一人民医院儿科,广东惠州516001 [2]广东省惠州市中医医院,广东惠州516001

出　　处：《河北医学》2015年第2期216-218,共3页Hebei Medicine

基　　金：广东省惠州市2009年科技计划资助项目;(编号:20090602)

摘　　要：目的:分析哮喘急性发作期、缓解期患儿血清IL-4及Ig E水平,探讨其临床意义。方法:选择35例支气管哮喘急性发作期患儿为观察组,35例支气管哮喘缓解期患儿为对照组,35例健康儿童为健康组。检查并比较各组IL-4、Ig E水平及肺功能,分析其相关性。结果:观察组与对照组IL-4及Ig E水平均显著高于健康组,差异均具有统计学意义(P<0.05)。且观察组IL-4及Ig E水平也显著高于对照组,差异均具有统计学意义(P<0.05)。观察组FEV1及PEF均显著低于对照组,差异具有统计学意义(P<0.05)。经person相关分析,哮喘发作期及缓解期患儿IL-4、Ig E与FEV1及PEF间均存在显著负相关(r=-0.786,-0.658,-0.865,-0.852,P<0.05)。结论:支气管哮喘患儿急性发作期IL-4及Ig E水平显著升高,肺功能相关指标明显降低,细胞因子IL-4及免疫球蛋白Ig E水平与患儿肺功能间存在显著负相关。Objective：To analyze the serum IL-4 and IgE levels of acute attack asthma and remission period asthma, to explore the clinical significance. Method：35 cases of acute attack bronchial asthma were as the observation group, 35 cases of bronchial asthma in remission stage were as control group, 35 healthy children as healthy group. IL-4,IgE levels and lung function in 3 groups were detected and compared, the correlation were analyzed. Result： IL-4 and IgE levels in observation group and control group were signifi-cantly higher than healthy group, The differences were statistically significant （P〈0.05）.The level of IgE and IL-4 in observation group was significantly higher than that in control group, The differences were statis-tically significant （P 〈 0.05）. The FEV1 and PEF of the observation group were significantly lower than those in the control group, The difference was statistically significant （ P〈0.05） . The person correlation anal-ysis showed that there were significant negative correlation among IL-4, IgE levels and FEV1 and PEF（ r=-0.786, -0.658,-0.865,-0.852, P〈0.05）. Conclusion：IL-4 and IgE levels in children with acute attack bronchial asthma significantly elevated, lung function decreased, There＇s significant negative correlation be-tween IL-4 and immunoglobulin IgE levels and lung function in children with cytokines.

关 键 词：支气管哮喘 肺功能 IL-4 IGE 免疫 

分 类 号：R725.6[医药卫生—儿科]