不同药物治疗有机磷农药中毒的临床比较  

Clinical Comparison of Different Drugs in Treatment of Acute Organophosphorus Pesticide Poisoning

作　　者：高宇[1] 张军建[1] 邹世斌[1] 

机构地区：[1]四川省自贡市第三人民医院ICU,四川自贡643000

出　　处：《河北医学》2015年第2期278-281,共4页Hebei Medicine

基　　金：2012年四川省卫生厅科研课题项目;(编号:120274)

摘　　要：目的:探讨长托宁抢救有机磷农药中毒(AOPP)的安全有效性。方法:将120例纳入研究的AOPP患者随机分成两组:观察组60例,应用长托宁治疗;对照组60例,应用阿托品治疗。比较两组的解毒恢复效果及不良反应。结果:观察组AOPP患者的总有效率93.33%,对照组AOPP患者的总有效率80.00%,观察组的疗效明显高于对照组(P<0.05);观察组AOPP患者的M样症状持续时间(1.70±0.45)h、N样症状持续时间(6.38±2.09)h和中枢神经系统症状持续时间(12.50±3.22)h均显著性短于对照组的(2.31±0.52)h、(10.25±4.88)h、(18.37±3.16)h(P<0.05);观察组AOPP患者所需的意识障碍恢复时间(23.46±11.30)h、Ch E活性恢复时间(46.81±13.27)h、住院天数(7.03±2.85)d均显著性少于对照组的(40.58±12.35)h、(63.50±18.94)h、(11.52±3.06)d(P<0.05);观察组的AOPP患者出现心动过速、躁动、视力模糊、尿潴留等不良反应的概率均明显低于对照组(P<0.05)。结论:长托宁治疗AOPP比阿托品更安全有效。Objective： To investigate the safety and effectiveness of penehyclidine hydrochloride in treatment of acute organophosphorus pesticide poisoning （ AOPP ） . Method： 120 cases of AOPP patients were randomly divided into two groups, observation group （n=60） and control group （n=60）.The observa-tion group was given penehyclidine hydrochloride, and the control group was given atropine. The detoxifying effects and adverse reactions in 2 groups were observed and compared. Result：The total efficiency rate was 93.33% in the observation group,the total efficiency rate was 80.00% in the control group, which was was significantly higher in the observation group than the control group （ P〈0.05）;the muscarinic-like symptoms duration （1.70 ± 0.45） h, nicotine-like symptoms duration （6.38 ± 2.09） h , and duration of symptoms of central nervous system （12.50±3.22） h in the observation group were significantly shorter than the control group（2.31±0.52）h,（10.25±4.88）h,（18.37±3.16）h （P〈0.05）;the consciousness recovery time（23.46± 11.30）h, ChE activity recovery time（46.81±13.27）h and hospital stay（7.03±2.85）d in the observation group were significantly shorter than the control group（40.58±12.35）h, （63.50±18.94）h,（11.52±3.06）d （ P〈0.05）;the major adverse reaction rates in the observation group were lower than the control group （ P〈0.05）. Conclusion：Penehyclidine hydrochloride in treatment of AOPP is safer and more effective than atro-pine.

关 键 词：有机磷农药中毒 长托宁 阿托品 不良反应 

分 类 号：R595.4[医药卫生—内科学]