滑膜间充质干细胞的生物学特性及其在软骨组织工程中应用的研究进展  

Biological characteristics and application of synovium derived mesenchymal stem cells in cartilage tissue engineering

作　　者：袁洋[1] 王思涵[1] 郭小凯[1] 刘畅[1] 

机构地区：[1]吉林大学口腔医院正畸科,吉林长春130021

出　　处：《海南医学》2015年第2期214-217,共4页Hainan Medical Journal

摘　　要：滑膜间充质干细胞(Synovium-derived mesenchymal stem cells,SMCSs)的增殖能力强,分离方法简便,具有多向分化潜能。其中SMSCs的成软骨分化能力尤为突出,被广泛应用于软骨缺损修复的实验中,因此SMSCs可能成为软骨组织工程领域中新的种子细胞,为关节软骨疾病治疗提供了新的可能性。本文对SMSCs的组织来源、生物学特性以及在软骨组织工程中的应用展开综述。Besides the general multipotency in common with other MSCs,synovium-derived mesenchymal stem cells exhibit easy access to cell resources and higher ability of proliferation and superiority in chondrogenesis.Under appropriate culture conditions,SMSCs were induced to differentiate into chondrocyte,osteocyte,and adipocyte lineages.This provides a new MSC-based therapeutic strategy for the repair of cartilage injury.This article expands overview of the tissue origin,biological characteristics of SMSCs and application in cartilage tissue engineering.

关 键 词：滑膜间充质干细胞 种子细胞 软骨组织工程 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]