盐酸氨溴索注射剂与常用抗菌药物配伍问题分析  

Analysis of Compatibility Change of Ambroxol Hydrochloride Injection with Various Antimicrobial Agents

作　　者：李文杰[1] 

机构地区：[1]中国人民解放军第251医院,河北张家口075000

出　　处：《中国药业》2015年第3期37-38,共2页China Pharmaceuticals

摘　　要：目的探讨盐酸氨溴索注射剂与抗菌药物配伍出现的问题,为合理用药提供参考。方法收集临床报告病例并查阅相关文献资料。结果盐酸氨溴索注射剂与有些抗菌药物配伍,会出现药液变色、浑浊、沉淀、不溶性微粒增加、p H改变、有效成分含量降低等现象,配伍不当还会发生不良反应。结论盐酸氨溴索注射剂不宜盲目与抗菌药物配伍使用。Objective To study the appearing problems in the compatibility of Ambroxol Hydrochloride Injection with the antimicrobial agents to provide reference for clinical rational drug use. Methods The reported clinical cases were collected and the related literatures were consuhed for conducting the comprehensive analysis. Results The compatibility of Ambroxol Hydrochloride Injection with some kinds of antimicrobial agents could appear some phenomena such as medical solution color change, turbidity, precipitation, insoluble particles in- crease, pH change and effective ingredient decrease. The improper compatibility would also lead to the adverse reactions. Conclusion Am- broxol Hydroehloride Injection should not be blindly used in the compatibility with some kinds of antimierobial agents.

关 键 词：盐酸氨溴索注射剂 抗菌药物 配伍稳定性 

分 类 号：R969.3[医药卫生—药理学] R974[医药卫生—药学]