甘精胰岛素联合吡格列酮治疗磺脲类继发失效2型糖尿病疗效观察  

The Effect of Glargine Combined with Pioglitazone in the Treatment of Secondary Failure of Sulfonylurea in Type 2 Diabetes

作　　者：李翔 

机构地区：[1]辽宁省大连市第五人民医院,辽宁大连116021

出　　处：《中国医学创新》2015年第1期57-60,共4页Medical Innovation of China

摘　　要：目的:探讨甘精胰岛素联合吡格列酮治疗磺脲类继发性失效的2型糖尿病的疗效。方法:60例患者随机数字表法分为A组和B组各30例;A组给予甘精胰岛素联合吡格列酮治疗,B组给予门冬胰岛素30R皮下注射,两组均治疗12周。测定治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹C肽(FCP)、餐后2 h C肽(2 h CP)及低血糖发生率。结果:治疗12周后,两组FBG、2 h PG和Hb A1c均明显下降,FCP和2h CP均明显升高,与治疗前比较差异有统计学意义(P<O.05),但组间比较差异无统计学意义。A组发生低血糖1例(3.3%),B组发生7例(23.3%),两组比较差异有统计学意义(P<O.05)。结论:甘精胰岛素联合吡格列酮治疗磺脲类继发性失效的2型糖尿病有较好疗效,治疗方便且易于掌握。Objective： To explore the effect of insulin glarage combined with pioglitazone in the treatment of type 2 diabetes. Method： 60 cases were randomly divided into group A and group B, 30 cases in each group. Group A was treated with insulin glargine combined with pioglitazone, while group B was given subcutaneous injection of insulin aspart 30 R. Both groups were treated for 12 weeks. To compare the fasting plasma glucose（FBG）, 2-hour postprandial plasma glucose（2 h PG）, glycosylated hemeglobi（Hb A1c）, fasting C-peptide（FCP）, 2-hour postprandial C-peptide（2 h CP） and incidence of low blood glucose before and after treatment. Result：After treatment for 12 weeks, the FBG, 2h PG and Hb A1 c of the two groups remarkably decreased, but the FCP and 2 h CP of the two groups significantly increased, and the differences were statistically significant（po.05）. But there were no statistical significant between the two groups（P〉0.05）. The low blood glucose reaction was noticed in 1 case（3.3%） in group A, but 7 cases（23.3%）in group B, and the differences were statistically significant（po.05）. Conclusion： Treating secondary failure of sulfonylurea in type 2 diabetes with insulin glargine combined with pioglitazone has good effect, and the method is simple, convenient and easy to master, which is worth clinical popularizing and application.

关 键 词：甘精胰岛素 吡格列酮 磺脲类继发性失效 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]