小青龙汤对慢性阻塞性肺疾病急性发作期患者肺功能及血清细胞因子的影响  

Impact of Xiaoqinglong Decoction on Lung Function and Serum Cytokines in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：吴亦文 刘涛 刘四平 

机构地区：[1]广东省深圳市光明新区中心医院,广东深圳518107

出　　处：《中国医学创新》2015年第1期109-111,共3页Medical Innovation of China

摘　　要：目的:观察并探讨小青龙汤(Xiaoqinglong Decoction,XQLD)对慢性阻塞性肺疾病急性发作期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的肺功能及血清细胞因子的影响。方法:选择2011年6月-2014年5月在本医院治疗的AECOPD患者96例,按照随机数字表法分为两组,观察组和对照组各48例,观察组给予在常规西医治疗的基础上加用XQLD治疗,而对照组仅给予常规西医治疗。治疗前后测量患者的肺功能指标,包括一秒用力呼气容积(FEV1)、用力肺活量(FVC)和最大呼气流速(PEF),并监测白介素-4(IL-4)、白介素-8(IL-8)和肿瘤坏死因子(TNF-α)的水平。结果:两组治疗前两组FEV1、FVC、PEF、IL-4、IL-8和TNF-α相比,差异不具有统计学意义;治疗后观察组FEV1、FVC和PEF分别为(1.28±0.38)L、(2.11±0.60)L和(3.12±1.29)L,对照组分别为(1.18±0.28)L、(2.02±0.53)L和(2.83±1.02)L,两组比较,差异具有统计学意义(P<0.05);治疗后,观察组IL-4、IL-8和TNF-α明显低于对照组,两组相比,差异具有统计学意义(P<0.05);观察组总有效率为91.7%(44/48),对照组为72.9%(35/48),比较差异具有统计学意义(P<0.05)。结论:XQLD联合西医治疗能明显改善AECOPD患者的肺功能,缓解炎症反应,疗效显著,是COPD急性期安全有效的疗法。Objective： To observe and explore the clinical value of Xiaoqinglong Decoction（XQLD） on lung function and serum cytokines in patients with acute exacerbation of Chronic obstructive pulmonary disease（AECOPD）. Method： 96 patients with AECOPD in this hospital since June 2011 to May 2014 were selected, 96 patients were randomized divided into two groups, each group contained 48 cases, the observation group was treated with XQLD on the basis of conventional Western medicine treatment, while the control group was treated with conventional western medicine. Lung function including forced expiratory volume in one second（FEV1）, forced vital capacity（FVC） and peak expiratory flow（PEF） in patients before and after treatment were measured, as well as interleukin-4（IL-4）, interleukin-8（IL-8） and tumor necrosis factor（TNF-α） levels were monitored. Result： The difference of FEV1, FVC, PEF, IL-4, IL-8 and TNF-α before treatment between the two groups was not statistically significant（P〈0.05）, after treatment FEV1, FVC and PEF in the observation group was（1.28±0.38）L,（2.11±0.60）L and（3.12±1.29）L, and（1.18±0.28）L,（2.02±0.53）L and（2.83±1.02）L in the control group, the difference was statistically significant（P〈0.05）. After treatment, IL-4, IL-8 and TNF-α level in the observation group was significantly lower than that of the control group, the difference was statistically significant（P〈0.05）. The total efficiency of observation group was 91.7%（44/48）, and for the control group was 72.9%（35/48）, the difference was statistically significant（P〈0.05）. Conclusion： XQLD combined western medicine can significantly improve lung function in patients with AECOPD, relieve inflammation, with a significant effect, thus is a safe and effective therapy for patients with acute COPD.

关 键 词：小青龙汤 COPD急性期 肺功能 细胞因子 

分 类 号：R563.9[医药卫生—呼吸系统]