中枢5-HT能系统在早发性抑郁中的作用研究  

Research on effect of central 5-HTergic system in early-onset depression

作　　者：郑莉明 史亚飞[1] 吴皓萌[1] 徐志伟[1] 

机构地区：[1]广州中医药大学基础医学院,广东广州510405

出　　处：《中国药理学通报》2015年第1期19-23,共5页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)项目子课题(No2011CB505103);国家自然科学基金资助项目(No81173144);广东省科技攻关项目(No 2012B031800206)

摘　　要：早发性抑郁的发病机制尚不明确。现仅有选择性5-HT重摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)SSRIs批准用于临床治疗早发性抑郁,显示出五羟色胺(5-hydroxytryptamine/serotonin,5-HT)5-HT是早发性抑郁发病机制中最重要的神经递质。目前有关中枢5-HT能系统在早发性抑郁中的作用研究主要集中在5-HT合成不足、5-HT运输功能障碍等方面,并与5-HT能系统较早发育成熟有关。色氨酸吸收障碍以及5-HT合成障碍都会导致5-HT合成不足;同时,5-HT转运体蛋白(5-HTT)基因多态性位点5-HTTLPR低转录效率基因型可能会增加早发性抑郁的患病风险。为进一步理解中枢5-HT能系统在早发性抑郁中的作用,未来需要进行更广泛更深入的基础及临床研究。Nowadays the pathogenesis of early-onset depression is still uncertain. Only SSRIs are currently approved for clinical use as antidepressants in children and adolescents, indicating that 5-HT is the most important neurotransmitter involved in the dis-ease. Current studies with regard to central 5-HTergic system in early-onset depression mainly focus on 5-HT synthesis deficien-cy, 5-HT transportation dysregulation, as well as the earlier mat-uration of 5-HT system than norepinephrine system. 5-HT precur-sor tryptophan malabsorption and dysregulation of 5-HT synthesis can contribute to 5-HT deficiency. Moreover, the 5-HTTLPR low-expressing genotypes may increase the risk of early-onset de-pression. It is necessary to make preclinical and clinical studies more widely and deeply about the effect of central 5-HTergic sys-tem in early-onset depression in future.

关 键 词：早发性抑郁 中枢5-HT能系统 5-HT 5-HTT 发育 成熟 SSRIS 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R394.2[医药卫生—基础医学]