尿路感染患儿产EL大肠埃希菌的研究进展  

Progress of E. coil producing extended spectrum beta-lactameses in children with urinary tract infection

作　　者：王灵芝[1] 朱光华[1] 康郁林[1] 

机构地区：[1]上海交通大学附属儿童医院上海市儿童医院肾脏风湿科,200040

出　　处：《国际儿科学杂志》2015年第1期14-17,共4页International Journal of Pediatrics

摘　　要：尿路感染（uiny infeion，咖）是儿童期多发病，随着广谱抗生素的大量使用，耐药菌株逐年增多，尤以大肠埃希菌（Eheihi oli，E．oli）为著。E oli耐药机制有产生药物水解酶、靶基因突变、主动外排泵和膜通透性的改变等，其中产超广谱．内酰胺酶（exended peum e．1me，E．L）E．oli日趋增多，给临床抗生素的选择提出了巨大挑战。根据其耐药基因（lEM、lHV、lX．M等）的不同分为不同类型（EM型、HV型、X-M型等）的EL。各种类型的EL对耐药基因的传播和流行起重要的作用，该文对目前已知耐药基因型的现状作一综述。Urinary tract infections（UTI）is a childhood disease. With the use of extended spectrum anti- biotics,resistant strains have increased every year,especially Escherichia cob（ E. coli）. The mechanisms of drug resistance are as follows ：hydrolase,target gene mutations, efflux pumps and membrane permeability change. Of which producing extended-spectrum 13-1actamase（ESBL）is increasing. So it presents a huge challenge to clinical antibiotic selection. According to the resistance genes （ blaTEM, blaSHV, blaCTX-M, etc. ）, the ESBL can be classified into different types （TEM type, SHV-type, CTX-M type, etc. ）. The drug-resistant genes play an important role in spreading and prevalence of the resistance genes. It＇s necessary to do a review of the currently known genotypes. It is both in favor of scientific research work and providing guidance for clinical work.

关 键 词：超广谱Β-内酰胺酶 大肠埃希菌 尿路感染 

分 类 号：R446.5[医药卫生—诊断学]