孤立性鼻骨发育异常预测21-三体胎儿  

Isolated abnormal fetal nasal bone for fetus with 21-trisomy

作　　者：刘彦英[1] 陈青[1] 赵晓虹[1] 吴丽桑[1] 许少兰[1] 丛淑珍[1] 

机构地区：[1]广东省人民医院广东省医学科学院超声科,广东广州510080

出　　处：《中国医学影像技术》2015年第1期95-97,共3页Chinese Journal of Medical Imaging Technology

基　　金：广东省医学科研基金(A2014050)

摘　　要：目的评估孤立性鼻骨发育异常预测21-三体胎儿的价值。方法回顾性分析产前诊断发现的32胎鼻骨发育异常胎儿,孕11-32周。将32胎鼻骨异常胎儿分为两组,孤立性鼻骨发育异常组（21胎）和非孤立性鼻骨发育异常组（即同时合并其他系统异常,11胎）。采用Fisher确切概率法比较两组间21-三体的发生率。结果孤立性鼻骨发育异常组21胎染色体结果均正常;非孤立性鼻骨发育异常组11胎中6胎染色体正常,5胎21-三体胎儿,二者21-三体胎儿发生率的差异有统计学意义（P=0.002）。结论鼻骨发育异常、且同时合并其他系统异常的胎儿为21-三体的风险较高;而孤立性鼻骨发育异常胎儿染色体异常的风险较小。Objective To evaluate the diagnostic value of isolated abnormal fetal nasal bone for fetus with 21-trisomy.Methods Totally 32fetuses（gestational age from 11 weeks to 32weeks）with abnormal nasal bone were analyzed retrospectively.All fetuses were categorized into isolated dysplasia nasal bone group（n=21）and non-isolated dysplasia group（with other systems abnormity,n=11）.The difference of incidence of 21-trisomy between two groups were compared by Fisher probabilities.Results All the 21 fetuses with isolated dysplasia nasal bone had normal karyotype.Among 11 fetuses in non-isolated dysplasia group,five fetuses with Down syndrome and six fetuses had normal karyotype.The difference of incidence of 21-trisomy between two groups were statistical significance（P=0.002）.Conclusion Fetuses with abnormal nasal nose and other systems abnormality have higher risk of 21-trisomy,comparing with fetuses of solitary bone dysplasia.

关 键 词：胎儿 染色体 鼻骨 超声检查 产前 

分 类 号：R714.53[医药卫生—妇产科学] R445.1[医药卫生—临床医学]