绝经后高血压患者左心室肥厚与颈动脉弹性功能的超声观察  

Ultrasonography of carotid artery and left ventricular function in post-menopausal hypertensive patients

作　　者：董瑾莹[1,2] 赵迎新[1] 李青[1] 王玉燕[1] 

机构地区：[1]天津中医药大学第二附属医院超声科,300150 [2]天津中医药大学

出　　处：《中国心血管杂志》2014年第6期434-437,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨绝经后高血压患者左心室肥厚(LVH)与颈动脉弹性功能的相关性。方法采用超声心动图检测85例绝经后高血压患者和40名年龄匹配绝经后健康女性(对照组)。按是否存在LVH,又将绝经后高血压患者分为LVH组45例和NLVH组40例。采用高频超声检测颈动脉扩张性(DC)、顺应性(CC)和僵硬度(β)作为评价弹性功能的指标。结果与对照组比较,NLVH组和LVH组的左心室质量指数(LVMI)和β升高[LVMI:(81.00±11.07)g/m2和(115.00±4.41)g/m2比(62.37±9.14)g/m2;β:7.29±2.75和11.34±4.24比5.96±2.50,均为P<0.05],DC和CC降低[DC:(1.95±0.68)×10-3/k Pa和(1.33±0.81)×10-3/k Pa比(3.04±1.27)×10-3/k Pa;CC:(0.44±0.11)mm2/k Pa和(0.35±0.19)mm2/k Pa比(0.67±0.19)mm2/k Pa,均为P<0.01]。与NLVH组比较,LVH组的LVMI和β进一步升高(均为P<0.01),DC和CC进一步降低(均为P<0.05)。LVH组患者的LVMI与雌二醇、DC和CC呈负相关(r=-0.374、-0.440、-0.382,均为P<0.05),与β呈正相关(r=0.554,P<0.01)。结论随着雌激素水平的降低,绝经后高血压患者LVH与颈动脉弹性功能受损存在相关性。Objective To investigate the correlation of left ventricular hypertrophy （LVH） with carotid artery （CCA） elasticity in post-menopausal hypertensive patients. Methods A total of 85 post- menopausal hypertensive patients and 40 healthy controls were studied by echocardiography. And elasticity index, including CCA distensibility, compliance and stiffness were measured by using high frequency ultrasonography. Results Compared to control group, LVMI and β were significantly increased and DC and CC significantly decreased in both NLVH group and LVH group [ LVMI： （81.00 ± 11.07）g/m2 and （115.00±4.41）g/m2 vs. （62.37 ±9.14）g/m2; DC： （1.95±0.68） ×10-3/kPa and （1.33±0.81） × 10-3/kPavs. （3.04±1.27） ×10- 3/kPa; CC： （0.44±0. 11） mm2/kPaand （0.35±0.19） mmZ/kPa vs. （0.67 ±0. 19） mm2/kPa, all P 〈0.01;β：7.29 ±2.75 and 11.34 ±4.24 vs. 5.96 ±2.50, both P 〈 0. 05 ]. LVMI and β in LVH group were significantly increased than in NLVH group [ （115. 00 ± 4. 41 ） g/m2vs. （81.00± 11.07） g/m2, 11.34±4.24 vs. 7.29 ±2.75, both P〈0.011, and DC and CC significantly decreased [（1.33 ±0.81） x 10-3/kPa vs. （1.95 ±0.68） × 10-3/kPa, （0.35 ± 0. 19） mm2/kPa vs. （0. 44 ± 0. 11 ） mm2/kPa, both P 〈 0. 05 ]. There were negative correlations between LVMI and E2 , DC, CC （r = - 0. 374, - 0. 440, - 0. 382, all P 〈 0. 05 ） , and positive correlation between LVMI and 13 （ r = 0. 554, P 〈 0. 01 ） in LVH group. Conclusions Left ventricular hypertrophy is correlated with carotid artery elasticity dysfunction in post-menopausal hypertensive patients.

关 键 词：绝经期 高血压 超声心动描记术 颈动脉 肥大 左心室 

分 类 号：R544.1[医药卫生—心血管疾病]