346例克林霉素注射剂致过敏性休克报告分析  

Analysis of 346 Allergic Shock Cases Caused by Clindamycin

作　　者：谢彦军[1] 田月洁[1] 刘翠丽[2] 路长飞 田春华[2] 

机构地区：[1]山东省药品不良反应监测中心,山东济南250013 [2]国家食品药品监督管理局药品评价中心,北京100045

出　　处：《中国药物警戒》2014年第12期749-752,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨克林霉素注射剂导致过敏性休克不良反应发生的影响因素和救治合理性,为有效降低用药风险提供参考。方法对国家药品不良反应监测报告系统中2009~2012年6月收集到346例由克林霉素导致过敏性休克不良反应数据进行统计分析。结果克林霉素注射剂导致过敏性休克与超说明书使用有一定的关联性,预后与及时诊断和合理救治关系密切。结论开展克林霉素安全性监测,及时合理选择和使用救治药品是降低风险的有效途径。Objective To investigate the influence factors and rational treatment of allergic shock caused by clindamycin. Methods 346 allergic shock cases caused by clindamycin in the national adverse drug reaction monitoring system between 2009 and June 2012 were analyzed. Results Allergic shock caused by clindamycin was related to the off-label use of drug. The prognosis has tight relationship with timely diagnosis and rational treatment. Conclusion Safety monitoring and timely treatment is the effective way to decrease risk of allergic shock of clindamycin.

关 键 词：克林霉素 过敏性休克 分析 

分 类 号：R978.19[医药卫生—药品] R994.11[医药卫生—药学]