吡拉西坦缓释固体分散体的制备及体外溶出度研究  

Research on Preparation and in Vitro Dissolution Rate of the Sustained Release Solid Dispersions of Piracetam

作　　者：王洁[1] 金刚[1] 薛健飞[1] 曲小姝[1] 张燕[1] 展瑞岩[1] 

机构地区：[1]吉林化工学院化学与制药工程学院,吉林吉林132022

出　　处：《吉林化工学院学报》2014年第11期25-27,共3页Journal of Jilin Institute of Chemical Technology

摘　　要：目的:采用溶剂-冷冻干燥法制备吡拉西坦(Piracetam)缓释固体分散体(SD)来减缓药物的释放速度.方法:分别选用乙基纤维素(EC)、羟丙甲基纤维素(HPMC)及甲基纤维素(MC)为载体制备吡拉西坦固体分散体,以体外溶出度为考查指标,选择最优载体.结果:当选用EC与HPMC的混合物为载体,且药物:EC HPMC的比例为1 3 0.7时,在2、6、12 h累计溶出度分别达到了30%、50%、80%左右,由此可见,将吡拉西坦制成固体分散体可起到很好的缓释效果.OBJECTIVE：Preparing the sustained release solid dispersions of piracetam to slow down the dissolution rate by the solvent-freeze drying method. METHODS： Selecting the optimal carriers from EC HPMC ,MC with the dissolution rate values. CONCLUSION ：When using the mixture of EC and HPMC as the carrier, the dissolution rate of the solid dispersion was 30% ,50% ,80% at 2,6,12 h, it had a better sustained release effect.

关 键 词：吡拉西坦 缓释 固体分散体 体外溶出度 

分 类 号：R94[医药卫生—药剂学]