厄贝沙坦联合辛伐他汀治疗充血性心力衰竭的疗效  

Therapeutic effect of irbesartan combined simvastatin treating congestive heart failure

作　　者：吴香梅 

机构地区：[1]河北省清苑县人民医院急诊科,河北清苑071100

出　　处：《心血管康复医学杂志》2014年第6期660-663,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探究厄贝沙坦联合辛伐他汀对充血性心力衰竭（CHF）的临床疗效.方法：选择在我院接受治疗的CHF患者286例,按随机数字表法均分为联合用药组（厄贝沙坦联合辛伐他汀治疗）和辛伐他汀组（辛伐他汀治疗）,治疗3个月,随访两组的疗效.结果：联合用药组总有效率显著高于辛伐他汀组（72.73％比48.95％,P＜0.01）;治疗后与辛伐他汀组比较,联合用药组左室射血分数[（33.6±4.5）％比（45.6±6.8）％]明显提高,左室舒张末期内径[（57.4±5.6） mm比（60.9±5.4） mm]、收缩末期内径[（46.7±3.2） mm比（49.5±3.5）mm],E/A比值[（0.84±0.12）比（1.45±0.31）]显著增大（P＜0.05～＜0.01）;联合用药组BNP水平在治疗3个月时显著低于辛伐他汀组[（790.8±91.1） pg/ml比（970.4±99.2） pg/ml,P＜0.05～＜0.01].结论：厄贝沙坦联合辛伐他汀治疗充血性心力衰竭疗效高,可以显著改善心功能.Objective： To explore clinical therapeutic effect of irbesartan combined simvastatin on congestive heart failure （CHF）. Methods： A total of 286 CHF patients treated in our hospital were selected. According to random number table, they were randomly and equally divided into combined medication group （received irbesartan combined simv- astatin） and simvastatin group （received simvastatin）, both groups were treated for three months. Therapeutic effects of two groups were followed up. Results.. Total effective rate of combined medication group was significantly higher than that of simvastatin group （72.73% vs. 48. 95%, P〈0. 01） ; compared with simvastatin group after treatment, there were sig- nificant rise in left ventricular ejection fraction [ （33.6 ± 4. 5） % vs. （45.6 ± 6. 8） %], left ventricular end-diastolic dimen- sion [ （57. 4 ± 5.6） mm vs. （60. 9± 5. 4） mm], end-systolic dimension [ （46. 7 ± 3.2） mm vs. （49. 5 ± 3.5） mm] and transmitral early diastolic peak flow velocity/transmitral late diastolic peak flow velocity [E/A, （0. 84 ± 0. 12） vs. （1.45 ± 0.31）J in combined medication group, P〈0. 05--〈0. 01; level of brain natriuretic peptide in combined medication group on 3-month after treatment was significantly lower than that of simvastatin group [ （790. 8 ± 91.1） pg/ml vs. （970. 4± 99.2） pg/ml, P〈0. 05-〈0.01]. Conclusion Simvastatin combined irbesartan possesses high therapeutic effect treating congestive heart failure. It can significantly improve heart function.

关 键 词：心力衰竭 厄贝沙坦 辛伐他汀 

分 类 号：R541.61[医药卫生—心血管疾病]