提高水飞蓟素生物利用度新技术的研究概况  

Research on improving bioavailability of silymarin by new technology

作　　者：庄珊珊[1,2] 陈菊明[1,2] 王文月[1,2] 宋洪涛[1] 

机构地区：[1]南京军区福州总医院药学科,福建福州350025 [2]福建医科大学药学院,福建福州350108

出　　处：《中国医院药学杂志》2014年第24期2158-2161,共4页Chinese Journal of Hospital Pharmacy

摘　　要：介绍近年来国内外对高生物利用度水飞蓟素剂型的研究现状。通过查阅文献,对水飞蓟素固体分散体、水飞蓟素磷脂复合物、水飞蓟素环糊精包合物、水飞蓟素自微乳药物、水飞蓟素立方液晶等进行综述。各类制剂学方法均能显著提高水飞蓟素生物利用度,对临床应用有重要意义。To introduce the domestic and foreign research status of high bioavailability of silymarin forrnulationsin recent years. Through the literature review, the silymarin solid dispersion, silymarin phytosomes, silymarin cyclodextrin inclusion compound, silymarin self-microernulsifying drug, silymarin cubic crystal are reviewed. Various preparation methods can significantly improve the silyrnarin bioavailability, is of great significance in clinical application.

关 键 词：水飞蓟素 生物利用度 新技术 

分 类 号：R943[医药卫生—药剂学]