肿瘤患者血小板抗体检测及配型在临床中的应用  

The clinical study of platelet antibodies detection and cross-matching experiment in tumor patients

作　　者：邵树军[1] 郝宝岚[1] 董晓锋[1] 叶昱坪[1] 郝新建[1] 王艳[1] 

机构地区：[1]郑州大学附属肿瘤医院 河南省肿瘤医院输血科,河南郑州450008

出　　处：《中国输血杂志》2014年第12期1327-1329,共3页Chinese Journal of Blood Transfusion

基　　金：河南省医学科技攻关计划项目(NO:2011020167)

摘　　要：目的通过比较相合输注组和随机输注组血小板的输注效果,评估血小板配型试验对血小板输注临床应用价值。方法检测600名肿瘤患者血小板抗体,64名抗体阳性患者随机分为相合输注组和随机输注组,检测2组患者输注后1 h和24 h血小板计数增高指数（CCI）和血小板恢复百分率（PPR）,相合组血小板配型次数与相合的关系。结果检出血小板抗体阳性的肿瘤患者64名（阳性率10.6%）,血小板配型在4～6人次时,相合比例最高达到56.3%;相合输注组患者与随机输注组相比,CCI值和PPR有效率明显提高,差异有统计学意义（P〈0.05）。结论血小板抗体检测及血小板配型输注可以为患者选择合适的血小板,提高血小板输注的有效率,避免血液资源的浪费。Objective To evaluate the clinical application value of platelet cross-matching experiment by comparing; the effect of matched transfusion and random transfusion of platelet. Methods 64 cases of platelet antibody-positive patients were divided into 2 groups ： a platelet matched transfusion group and a random transfusion group. CCI （ corrected count incre- ment） and PPR （percentage platelet recovery） were recorded after the transfusion at 1-hour and 24-hour. Results The platelet antibody-positive patients were 64 cases, with a positive rate at 10. 6%. The highest match rate was 56. 3% when cressmatching involved 4 to 6 people. Matched transfusion group had higher CCI and PPR than random transfusion group ~th statistical significance （P 〈 0. 01 ）. Conclusion Platelet antibodies detection and cross-matching experiment could select matching and suitable platelet for patients, increase effective rate of platelet transfusion and reasonably avoid waste of pre-cious blood resources.

关 键 词：肿瘤患者 血小板抗体 配型 

分 类 号：R457.11[医药卫生—治疗学]